Curriculum Vitae

Zhimulev Igor
Academician RAS
 
phone: +7-383-3301665
fax: +7-383-3635153
e-mail: zhimulevatmcb [dot] nsc [dot] ru
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Born

01.01.1947, Stepanokert, Azerbaijan (USSR)

Education and Academic Employment

1971 – Diploma with honors, Gorky State University (currently State University of Nizhni Novgorod)

1971-1974 – PhD student, Institute of Cytology and Genetics (ICG), Novosibirsk, USSR

1974-1979 – Junior research fellow, ICG, Novosibirsk, USSR

1975 – PhD degree in biology, “Transcription activity of Drosophila melanogaster polytene chromosomes”, Institute of Developmental Biology, Moscow, USSR

1979-1982 – Senior research fellow, ICG, Novosibirsk, USSR

1982 – DSc degree in biology, “Chromomeric organization of polytene chromosomes”, ICG, Novosibirsk, USSR

1982-1986 – Group leader, ICG, Novosibirsk, USSR

1986-2007 – Head of the Laboratory of molecular cytogenetics, ICG, Novosibirsk, Russia

1991-2007 – Professor of the Novosibirsk State University, Russia

2007-2009 – Head of the Department of molecular and cellular biology, ICG, Novosibirsk, Russia

2009-2011 – Deputy Director, Head of the Department of molecular and cellular biology, Head of the Laboratory of Molecular Cytogenetics, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia

2011-2012 – Director-organizer of the Institute of Molecular and Cellular Biology, Novosibirsk, Russia

2012-2017 – Director of the Institute of Molecular and Cellular Biology, Novosibirsk, Russia

since 2017 – Head of the Laboratory of Molecular Cytogenetics, Institute of Molecular and Cellular Biology, Novosibirsk, Russia

since 2017 – Scientific supervisor of the Institute of Molecular and Cellular Biology, Novosibirsk, Russia

Membership in Academies, Scientific Councils and Scientific Societies
  • Central Council of the Vavilov’s Society of Geneticists (since 1982)
  • Academic Council of the Russian Academy of Sciences on the problems of genetics (since 1988)
  • Scientific Council on Molecular Biology of the Russian Academy of Sciences (since 1988)
  • General Council on Natural Sciences of Siberian Department of the Russian Academy of Sciences (since 1988)
  • Scientific Council on Cell Biology of the Russian Academy of Sciences (since 1999)
  • Corresponding Member of the Russian Academy of Natural Sciences (1991-1999)
  • Full member of the Russian Academy of Natural Sciences (since 1999)
  • Professor of Genetics (since 1993)
  • Academia Europaea (since 1995)
  • Soros Professor (since 1995)
  • Chief of the Novosibirsk Department of Vavilov’s Society of Geneticists (sine 2004)
  • Scientific Council on genetics and selection of the Russian Academy of Sciences (since 2007)
  • Corresponding Member of the Russian Academy of Sciences (1997-2006)
  • Full member of the Russian Academy of Sciences (since 2006)
Editorial Boards
  • BioEssays (Germany)
  • Journal of Biological Research (Greece)
  • Russian Journal of Genetics (Moscow, Russia) (1988-2011) 
  • Russian Cytology Journal (St.-Petersburg, Russia)
  • VOGiS Herald (Novosibirsk, Russia)
  • Siberian Journal of Ecology (Novosibirsk, Russia)
Awards
  • Award of Siberian Branch of the Academy of Sciences of USSR (biology), second grade (1984)
  • Vavilov’s medal for the achievements in genetics (1987)
  • Council on Molecular Biology of RAS (Russian Academy of Sciences), first grade (1993)
  • Koltsoff Prize of the Russian Academy of Sciences (2000)
  • State Prize of Russian Federation (2002)
  • Medal of the Order “For Services for Fatherland”, second grade (2008)
  • Order of Saint Stanislaus, the third class (2012)
  • Commemorative Medal in honor of the 60th anniversary of SB RAS (2017)
Fields of Research

Genetics, cytogenetics, structural and functional organization of polytene chromosomes, genetic content of interbands, bands and puffs, chromatin organization in interphase chromosomes, pericentric and intercalary heterochromatin, position effect variegation, transcriptional and replicative activity of polytene chromosomes, hormonal control of genes activity in the salivary gland cells of Drosophila

Scientific Results

The main area of investigations is molecular and genetic organization of polytene chromosomes of Drosophila as a model of interphase chromosome of eukaryote. In his works the concept of dynamic chromomere organization of chromosomes was raised and proved experimentally. He predicted and demonstrated cytogenetic and molecular anatomy of individual chromomere, showed its polygeny and functional independence of the genes being its parts. He obtained the evidence of transcriptional activity of interchromomeres and cloned DNA sequence of interchromomere region using P-element mediated transformation. He formulated the idea of heterochromatic regions as a system of highly repressed parts of genome. He discovered the genes controlling both hormonal induction the genes and structure and replication of chromosomes, he described the components of the system of genetic silencing of the early embryogenesis genes and the genes under position effect variegation. He discovered the gene clusters with coordinated replication and expression ion the genome of Drosophila. He elaborated the concept of functional organization of interphase chromosomes and chromomeres. He developed the idea of puffing as a base of differential expression of genes, described the puff spectrums in development and the mechanisms of hormonal control. He pioneered the molecular analysis of the cloned puff, controlled by ecdysteron, demonstrated the complex organization of gene there placed; he formulated the idea of intercalary heterochromatin as highly repressed chromosome regions and described its parameters. He grounded the idea of position effect variegation mechanism, functioning as a result of DNA compactization under influence of inactive heterochromatin

Selected Publications

More than 350 scientific works including 3 monographs on Russian and 3 monographs on English (published in Academic Press, USA), 4 editions of the textbooks “General and molecular genetics” (in Russian) and the textbook “Chromosomes. Structure and functions”

  • Zhimulev IF. Morphology and structure of polytene chromosomes. Adv Genet 34: 1-497, 1996
  • Zhimulev IF. Heterochromatin and position effect variegation. Adv Genet 37: 1-566, 1998
  • Zhimulev IF. Genetic organization of polytene chromosomes. Adv Genet 39: 1-599, 1999
  • Zhimulev IF. General and Molecular Genetics (Textbook for Students). Fourth Edition. Siberian University Publishing, Novosibirsk, 479 pp., 2007 (in Russian)
  • Koryakov DE, Zhimulev IF. Chromosomes. Structure and Functions (Textbook for Students). Publishing Company of SD RAS, Novosibirsk, 257 pp., 2009 (in Russian)
  • Belyaeva ES, Zhimulev IF, Volkova EI, Alekseyenko AA, Moshkin YM, Koryakov DE. Su(UR)ES a gene suppressing DNA underreplication in intercalary and pericentric heterochromatin of Drosophila melanogaster polytene chromosomes. Proc Natl Acad Sci USA 95: 7532-7537, 1998
  • Moshkin YM, Alekseyenko AA, Semeshin VF, Spierer A, Spierer P, Makarevich GF, Belyaeva ES, Zhimulev IF. The Bithorax Complex of Drosophila melanogaster. Underreplication and morphology in polytene chromosomes. Proc Natl Acad Sci USA 98: 570-574, 2001
  • Holt RA,… Kokoza EB, Zhimulev IF,… Kafatos FC. The genome sequence of the malaria mosquito Anopheles gambiae. Science 298: 129-149, 2002
  • Koryakov DE, Zhimulev IF, Dimitri P. Cytogenetics analysis of the third chromosome heterochromatin of Drospohila melanogaster. Genetics 160: 509-517, 2002
  • Makunin IV, Volkova EI, Belyaeva ES, Nabirochkina EN, Pirrotta V, Zhimulev IF. The Drosophila Suppressor of Underreplicationprotein binds to late-replicating regions of polytene chromosomes. Genetics 160: 1023-1034, 2002
  • Zhimulev IF, Belyaeva ES, Semeshin VF, Shloma VV, Makunin IV, Volkova EI. Overexpression of Drosophila melanogaster SuUR gene results in reversible chromatin reorganization at polytene chromosome pericentric, telomeric and intercalary heterochromatin. J Cell Sci 116: 169-176, 2003
  • Koryakov DE, Domanitskaya EV, Belyakin SN, Zhimulev IF. Abnormal tissue-dependent polytenization of a block of chromosome 3 pericentric heterochromatin in Drosophila melanogaster. J Cell Sci 116: 1035-1044, 2003
  • Cherbas LF, Hu X, Zhimulev I, Belyaeva E, Cherbas P. EcR isoforms in Drosophila: Testing tissue-specific requirements by targeted blockade and rescue. Development 130: 271-284, 2003
  • Zhimulev IF, Belyaeva ES, Makunin IV, Pirrotta V, Volkova EI, Alekseyenko AA, Andreyeva EN, Makarevich GF, Boldyreva LV, Nanayev RA, Demakova OV. Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes. Chromosoma 111: 377-398, 2003
  • Zhimulev IF, Belyaeva ES. Intercalary heterochromatin and genetic silencing. BioEssays 25: 1040-1050, 2003
  • Demakova OV, Kotlikova IV, Gordadze PR, Alekseenko AA, Kelley RL, Kuroda MI, Zhimulev IF. The MSL complex levels are critical for its correct targeting to the chromosomes in Drosophila melanogaster. Chromosoma 112: 103-115, 2003
  • Belyaeva ES, Boldyreva LV, Volkova EI, Nanayev RA, Alekseyenko AA, Zhimulev IF. Effect of the Suppressor of Underreplication gene (SuUR) on PEV-silencing in Drosophila melanogaster. Genetics 165: 1209-1220, 2003
  • Zhimulev IF, Belyaeva ES, Semeshin VF, Koryakov DE, Demakov SA, Demakova OV, Pokholkova GV, Andreyeva EN. Polytene chromosomes: 70 years in genetic research. Int Rev Cytol 241: 203-275, 2004
  • Degtyarev S, Boykova T, Grishanin A, Belyakin S, Rubtsov N, Karamysheva T, Makarevich G, Akifyev A, Zhimulev I. The molecular structure of the DNA fragments eliminated during chromatin diminution in Cyclops kolensis. Genome Res 14: 2284-2294, 2004
  • Belyakin SN, Christophides GK, Alekseyenko AA, Nanayev RA, Boldyreva LV, Belyaeva ES, Makunin IV, Heidelberg Fly Array Consortium, Kafatos FC, Zhimulev IF. Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories. Proc Natl Acad Sci USA 102: 8269-8274, 2005
  • Gortchakov AA, Eggert H, Gan M, Mattow J, Zhimulev IF, Saumweber H. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Chromosoma 114: 54-66, 2005
  • Koryakov DE, Reuter G, Dimitri P, Zhimulev IF. The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster. Chromosoma 115: 296-310, 2006
  • Salvaing J, Decoville M, Mouchel-Vielh E, Bussiere M, Daulny A, Boldyreva L, Zhimulev I, Locker D, Peronnet F. Corto and DSP1 interact and bind to a maintenance element of the Scr Hoxgene: understanding the role of Enhancers of trithorax and Polycomb. BMC Biology 4: 9, 2006
  • Belyaeva ES, Demakov SA, Pokholkova GV, Alekseyenko AA, Kolesnikova TD, Zhimulev IF. DNA underreplication in intercalary heterochromatin regions in polytene chromosomes of Drosophila melanogaster correlates with the formation of partial chromosomal aberrations and ectopic pairing. Chromosoma 115: 355-366, 2006
  • Demakova OV, Pokholkova GV, Kolesnikova TD, Demakov SA, Andreyeva EN, Belyaeva ES, Zhimulev IF. The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster. Genetics 175: 609-620, 2007
  • Pindyurin AV, Moorman C, de Wit E, Belyakin SN, Belyaeva ES, Christophides GK, Kafatos FC, van Steensel B, Zhimulev IF. SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila. J Cell Sci 120, 2344-2351, 2007
  • Andreyeva EN, Kolesnikova TD, Demakova OV, Mendez-Lago M, Pokholkova GV, Belyaeva ES, Rossi F, Corradini N, Dimitri P, Villasante A, Zhimulev IF. High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants. Proc Natl Acad Sci USA 104: 12819-12824, 2007
  • Pindyurin AV, Boldyreva LV, Shloma VV, Kolesnikova TD, Pokholkova GV, Andreyeva EN, Kozhevnikova EN, Ivanoschuk IG, Zarutskaya EA, Demakov SA, Gorchakov AA, Belyaeva ES, Zhimulev IF. Interaction between the Drosophila heterochromatin proteins SUUR and HP1. J Cell Sci 121: 1693-1703, 2008
  • Zhimulev IF, Koryakov DE. Polytene chromosomes. In: Encyclopedia of Life Sciences (ELS), John Wiley & Sons, Ltd: Chichester, 2009
  • Yurlova AA, Makunin IV, Kolesnikova TD, Posukh OV, Belyaeva ES, Zhimulev IF. Conservation of domain structure in a fast-evolving heterochromatic SUUR protein in drosophilids. Genetics 183: 119-129, 2009
  • Andreyenkova NG, Kokoza EB, Semeshin VF, Belyaeva ES, Demakov SA, Pindyurin AV, Andreyeva EN, Volkova EI, Zhimulev IF. Localization and characteristics of DNA underreplication zone in the 75C region of intercalary heterochromatin in Drosophila melanogaster polytene chromosomes. Chromosoma 118: 747-761, 2009
  • Belyakin SN, Babenko VN, Maksimov DA, Shloma VV, Kvon EZ, Belyaeva ES, Zhimulev IF. Gene density profile reveals the marking of late replicated domains in the Drosophila melanogaster genome. Chromosoma 119: 589-600, 2010
  • Babenko VN, Makunin IV, Brousentsova IV, Belyaeva ES, Maksimov DA, Belyakin SN, Maroy P, Vasil’eva LA, Zhimulev IF. Paucity and preferential suppression of transgenes in late replication domains of the D. melanogaster genome. BMC Genomics 11: 318, 2010
  • Vatolina TYu, Boldyreva LV, Demakova OV, Demakov SA, Kokoza EB, Semeshin VF, Babenko VN, Goncharov FP, Belyaeva ES, Zhimulev IF. Identical functional organization of cell line interphase and polytene chromosomes in Drosophila melanogaster. PLoS ONE 6(10): e25960, 2011
  • Demakov SA, Vatolina TYu, Babenko VN, Semeshin VF, Belyaeva ES, Zhimulev IF. Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. BMC Genomics 12: 566, 2011
  • Zhimulev IF, Belyaeva ES, Vatolina TYu, Demakov SA. Banding patterns in Drosophila melanogaster polytene chromosomes correlate with DNA-binding protein occupancy. BioEssays 34: 498-508, 2012
  • Andreyenkova NG, Kolesnikova TD, Makunin IV, Pokholkova GV, Boldyreva LV, Zykova TYu, Zhimulev IF, Belyaeva ES. Late replication domains are evolutionary conserved in the Drosophila genome. PLoS ONE 8(12): e83319, 2013
  • Zhimulev IF, Zykova TYu, Goncharov FP, Khoroshko VA, Demakova OV, Semeshin VF, Pokholkova GV, Boldyreva LV, Demidova DS, Babenko VN, Demakov SA, Belyaeva ES. Genetic organization of interphase chromosome bands and interbands in Drosophila melanogaster. PLoS ONE 9(7): e101631, 2014
  • Nordman JT, Kozhevnikova EN, Verrijzer CP, Pindyurin AV, Andreyeva EN, Shloma VV, Zhimulev IF, Orr-Weaver TL. DNA copy-number control through inhibition of replication fork progression. Cell Reports 9: 841–849, 2014
  • Khoroshko VA, Levitsky VG, Zykova TY, Antonenko OV, Belyaeva ES, Zhimulev IF. Chromatin heterogeneity and distribution of regulatory elements in the late-replicating intercalary heterochromatin domains of Drosophila melanogaster chromosomes. PLoS ONE 11(6): e0157147, 2016
  • Andreyeva EN, Bernardo TJ, Kolesnikova TD, Lu X, Yarinich LA, Bartholdy BA, Guo X, Posukh OV, Healton S, Willcockson MA, Pindyurin AV, Zhimulev IF, Skoultchi AI, Fyodorov DV. Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in DrosophilaGenes Dev 31: 603-616, 2017
Lectures

1980

  • University of Cambridge, UK
  • University of Oxford, UK
  • University of Sheffield, UK

1982

  • University of Madrid, Spain

1984

  • University of Madrid, Spain
  • University of Valencia, Spain

1986

  • Genetics Centre in Szeged, Hungary

1987

  • University of Halle, Germany
  • Institute of Plant Genetics in Gatersleben, Germany

1988

  • University of Madrid, Spain
  • University of Valencia, Spain

1990

  • University of Thessaloniki, Greece

1993

  • Harvard University, Boston, USA
  • University of Washington, Seattle, USA
  • University of California, Berkeley, USA
  • Indiana University, USA
  • University of North Caroline, USA

1995

  • Institute of Molecular Biology in Heidelberg, Germany

1998

  • University of Jacques Mono in Paris, France
  • Marceille University, France
  • University of Zurich, Switzerland
  • University of Geneve, Switzerland

2000

  • University of Zurich, Switzerland
  • University of Geneve, Switzerland

2003

  • University of Halle, Germany

2007

  • University of Madrid, Spain
Conferences
  • XIII International EMBO Workshop on Molecular and Developmental Biology of Drosophila, Kolymbari, Crete, Greece, 1998
  • VI European Congress of Entomology, Ceske Budejovice, Czech Republic, 1998
  • XIV International EMBO Workshop on Molecular and Developmental Biology of Drosophila, Kolymbari, Crete, Greece, 2000
  • 5th International Conference on Drosophila heterochromatin, Cortona, Italy, 2001
  • 14th International Chromosome Conference, Wurzburg, Germany, 2001
  • XV International EMBO Workshop on Molecular and Developmental Biology of Drosophila, Kolymbari, Crete, Greece, 2002
  • 6th International Conference on Drosophila heterochromatin, Ravello, Italy, 2003
  • 19th European Drosophila Research Conference, Eger, Hungary, 2005
  • 7th International Conference on Drosophila Heterochromatin, Gubbio, Italy, 2005
  • 8th International Conference on Drosophila Heterochromatin, Gubbio, Italy, 2007
  • XVI EMBO Workshop on Molecular and Developmental Biology of Drosophila, Kolymbari, Crete, Greece, 2008
  • 9th International Conference on Drosophila Heterochromatin, Gubbio, Italy, 2009
  • International Conference “Chromosome 2009”, Novosibirsk, Russia, 2009
  • 21st European Drosophila Research Conference, Nice, France, 2009
  • 52nd Annual Drosophila Research Conference, San Diego, USA, 2011
  • 10th International Conference on Drosophila Heterochromatin, Gubbio, Italy, 2011
  • 11th International Conference on Drosophila Heterochromatin, Lecce, Italy, 2013