Department of the Structure and Function of Chromosomes

Laboratory of Molecular Genetics

Vershinin Alexander
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Vershinin Alexander head DSc (Biology) avershinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Evtushenko Elena senior research fellow PhD (Biology) evtatmcb [dot] nsc [dot] ru
thomson_logo.gif     Terletsky Alexander research fellow PhD (Biology) terletskyatmcb [dot] nsc [dot] ru
thomson_logo.gif     Gatskaya Sima junior research fellow  
      Trunin Sergey research assistant    
  scopus_logo.jpg   Titov Sergey part-time senior research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg   Veryaskina Yulia part-time research fellow PhD (Biology) juliaveratmcb [dot] nsc [dot] ru
      Elisaphenko Evgeny part-time research fellow PhD (Biology)  
      Gunbin Konstantin part-time research fellow PhD (Biology)  
  scopus_logo.jpg   Ivanov Mikhail part-time research fellow PhD (Biology)  
      Kovynev Igor part-time research fellow PhD (Biology)  
      Malakhina Ekaterina part-time research assistant PhD (Medicine)  
      Klimova Olesya part-time research assistant    
      Serdyukova Olga part-time lab technician    
      Maslov Konstantin part-time research assistant    

Former research workers:

Gaskov Dmitry
Grishko Ekaterina
Kolesnikov Nikolay, DSc
Lipikhina Yulia

Recent publications: 
  1. Titov SE, Kozorezova ES, Demenkov PS, Veryaskina YA, Kuznetsova IV, Vorobyev SL, Chernikov RA, Sleptsov IV, Timofeeva NI, Ivanov MK. Preoperative typing of thyroid and parathyroid tumors with a combined molecular classifier. (doi: 10.3390/cancers13020237Cancers 13(2): 237, 2021

  2. Kovynev IB, Titov SE, Ruzankin PS, Agakishiev MM, Veryaskina YA, Nedel’ko VM, Pospelova TI, Zhimulev IF. Profiling 25 bone marrow microRNAs in acute leukemias and secondary nonleukemic hematopoietic conditions. (doi: 10.3390/biomedicines8120607Biomedicines 8(12): 607, 2020

  3. Ellis THN, Vershinin AV. Retrotransposons and the evolution of genome size in Pisum. (doi: 10.3390/biotech9040024) BioTech 9(4): 24, 2020

  4. Titov S, Demenkov PS, Lukyanov SA, Sergiyko SV, Katanyan GA, Veryaskina YA, Ivanov MK. Preoperative detection of malignancy in fine-needle aspiration cytology (FNAC) smears with indeterminate cytology (Bethesda III, IV) by a combined molecular classifier. (doi: 10.1136/jclinpath-2020-206445J Clin Pathol 73(11): 722-727, 2020

  5. Koroleva AG, Evtushenko EV, Vershinin AV, Zaytseva EP, Timoshkin OA, Kirilchik SV. Age dynamics of telomere length in endemic Baikal planarians (doi: 10.1134/S002689332004007X) Mol Biol 54(4): 553-562, 2020

  6. Veryaskina YuA, Titov SE, Kovynev IB, Pospelova TI, Zhimulev IF. The miRNA profile in non-Hodgkin’s lymphoma patients with secondary myelodysplasia. (doi: 10.3390/cells9102318Cells 9(10): 2318, 2020

  7. Veryaskina YuA, Titov SE, Kovynev IB, Pospelova TI, Zhimulev IF. Prognostic markers of myelodysplastic syndromes. (doi: 10.3390/medicina56080376Medicina 56(8): 376, 2020

  8. Veryaskina YuA, Titov SE, Kometova VV, Rodionov VV, Zhimulev IF. Intratumoral heterogeneity of expression of 16 miRNA in luminal cancer of the mammary gland. (doi: 10.3390/ncrna6020016Non-Coding RNA 6(2): 16, 2020

  9. Evtushenko EV, Lipikhina YuA, Stepochkin PI, Vershinin AV. Cytogenetic and molecular characteristics of rye genome in octoploid triticale (× Triticosecale Wittmack). (doi: 10.3897/CompCytogen.v13i4.39576Comp Cytogenet 13(4): 423-434, 2019

  10. Titov SE, Ivanov MK, Demenkov PS, Katanyan GA, Kozorezova ES, Malek AV, Veryaskina YuA, Zhimulev IF. Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears. (doi: 10.1186/s12885-019-6154-7BMC Cancer 19: 1010, 2019

  11. Kolesnikov NN, Veryaskina YuA, Titov SE, Rodionov VV, Gening TP, Abakumova TV, Kometova VV, Torosyan MKh, Zhimulev IF. Expression of micrornas in molecular genetic breast cancer subtypes. (doi: 10.1016/j.ctarc.2016.08.006) Cancer Treat Res Commun 20: 100026, 2019

  12. Terletsky AV, Akhmerova LG, Evtushenko EV. Blood parasite infection causing inflammatory reactions and benign formations in human thyroid gland. (doi: 10.15789/2220-7619-2019-1-155-161) Rus J Infection Immunity 9(1): 155-161, 2019

  13. Gatzkaya SS, Evtushenko EV. Patterns of nucleotide diversity for different domains of centromeric histone H3 (CENH3) gene in Secale L. (doi: 10.18699/VJ19.472) Vavilov J Genetics Breeding 23(2): 135-139, 2019

  14. Serdyukova OS, Titov SE, Malakhina ES, Rymar OD. MicroRNAs – promising molecular markers for detecting cancer in thyroid nodules. (doi: 10.14341/ket9774) Clinical and experimental thyroidology 14(3): 140-148, 2018 (Abstract in English)

  15. Lipikhina YuA, Evtushenko EV, Lyusikov OM, Gordei IS, Gordei IA, Vershinin AV. Dynamics of the centromeric histone CENH3 structure in rye-wheat amphidiploids (Secalotriticum). (doi: 10.1155/2018/2097845BioMed Res Int 2018: 2097845, 2018

  16. Ovsyannikova AK, Rymar OD, Ivanoshchuk DE, Mikhailova SV, Shakhtshneider EV, Orlov PS, Malakhina ES, Voevoda MI. A case of maturity onset diabetes of the young (MODY3) in a family with a novel HNF1A gene mutation in five generations. (doi: 10.1007/s13300-017-0350-8Diabetes Ther 9(1): 413-420, 2018

  17. Ivanov MK, Titov SE, Glushkov SA, Dzyubenko VV, Malek AV, Arkhangelskaya PA, Samsonov RB, Mikhetko AA, Bakhidze EV, Berlev IV, Kolesnikov NN. Detection of high-grade neoplasia in air-dried cervical PAP smears by a microRNA-based classifier. (doi: 10.3892/or.2018.6214Oncology Rep 39: 1099-1111, 2018 

  18. Lipikhina YA, Evtushenko EV, Elisafenko EA, Vershinin AV. Chromosomal assignment of centromere-specific histone CENH3 genes in rye (Secale cereale L.) and their phylogeny. (doi: 10.3897/CompCytogen.v11i4.19953Comp Cytogenet 11(4): 821-832, 2017

  19. Evtushenko EV, Elisafenko EA, Gatzkaya SS, Lipikhina YA, Houben A, Vershinin AV. Conserved molecular structure of the centromeric histone CENH3 in Secale and its phylogenetic relationships. (doi: 10.1038/s41598-017-17932-8Sci Reports 7: 17628, 2017

  20. Stolyar M, Klimova O, Ivanov M, Gorbenko A, Titov S, Olkhovskiy I. JAK2 haplotype 46/1 (GGCC) has no effect on the primary risk of JAK2 V617F mutation, but it strongly potentiates the progression of grown allele burden in myeloproliferative neoplasms. Haematologica 102(s2): 539, 2017

  21. Malek A, Sleptsov I, Cheburkin Y, Samsonov R, Kolesnikov N. miRNA as potential tool for thyroid cancer diagnostics and follow up: practical considerations. JSM Thyroid Disord Manag 2(1): 1007, 2017

  22. Boldyreva LV, Goncharov FP, Demakova OV, Zykova TYu, Levitsky VG, Kolesnikov NN, Pindyurin AV, Semeshin VF, Zhimulev IF. Protein and genetic composition of four chromatin types in Drosophila melanogaster cell lines. (doi:  10.2174/1389202917666160512164913Curr Genomics, 18(2): 214-226, 2017

  23. Stupak EV, Veryaskina YuA, Titov SE, Achmerova LG, Stupak VV, Ivanov MK, Zhimulev IF, Kolesnikov NN. MicroRNA profiling in the malignant progression of gliomas. AIP Conf Proc 1760, 020065, doi: 10.1063/1.4960284, 2016

  24. Evtushenko  EV, Levitsky VG, Elisafenko EA, Gunbin KV, Belousov AI, Šafář J, Doležel J, Vershinin AV. The molecular mechanisms of heterochromatin expansion in rye chromosomes. Cytogenet Genome Res 148: 91, 2016

  25. Titov SE, Demenkov PS, Ivanov MK, Malakhina ES, Poloz TL, Tsivlikova EV, Ganzha MS, Shevchenko SP, Gulyaeva LF, Kolesnikov NN. Selection and validation of miRNAs as normalizers for profiling expression of microRNAs isolated from thyroid fine needle aspiration smears. (doi: 10.3892/or.2016.5113Oncology Rep 36: 2501-2510, 2016

  26. Samsonov R, Burdakov V, Shtam T, Radzhabovа Z, Vasilyev D, Tsyrlina E, Titov S, Ivanov M, Berstein L, Filatov M, Kolesnikov N, Gil-Henn H, Malek A. Plasma exosomal miR-21 and miR-181a differentiates follicular from papillary thyroid cancer. (doi: 10.1007/s13277-016-5065-3Tumor Biol 37: 12011-12021, 2016

  27. Evtushenko EV, Levitsky VG, Elisafenko EA, Gunbin KV, Belousov AI, Šafář J, Doležel J, Vershinin AV. The expansion of heterochromatin blocks in rye reflects the co-amplification of tandem repeats and adjacent transposable elements. (doi: 10.1186/s12864-016-2667-5BMC Genomics 17(1): 337, 2016

  28. Titov SE, Ivanov MK, Karpinskaya EV, Tsivlikova EV, Shevchenko SP, Veryaskina YA, Akhmerova LG, Poloz TL, Klimova OA, Gulyaeva LF, Zhimulev IF, Kolesnikov NN. miRNA profiling, detection of BRAF V600E mutation and RET-PTC1 translocation in patients from Novosibirsk oblast (Russia) with different types of thyroid tumors. (doi: 10.1186/s12885-016-2240-2BMC Cancer 16: 201, 2016

  29. Shevchenko S, Mostovich L, Kolesnikov N, Gulyaeva L. Molecular biomarkers in preoperative diagnosis of thyroid cancer. Eur J Cancer Suppl 13(1): 52, 2015

Selected talks: 
  1. Evtushenko EV. Evolutionary dynamics of the centomeric histone CENH3 in the Triticeae tribe. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  2. Vershinin A. The molecular mechanisms of the heterochromatin expansion in the rye chromosomes. 21st International Chromosome Conference. July 10-13, 2016, Foz do Iguaçu, Brazil

  3. Vershinin AV. Intensive recombinations have led to tandem repeat expansion and enlargement of rye subtelomeric heterochromatin. The 19th International Chromosome Conference. 2-6 September 2013, Bologna, Italy

  4. Vershinin AV. Genomics of rye subtelomeric heterochromatin. 11th Gatersleben Research Conference "Chromosome biology, genome evolution, and speciation" 23-25 April 2012, Gatersleben, Germany

  5. Vershinin AV. The genomics of the most abundant tandem repeat DNA families in the rye heterochromatin. Annual Main Meeting of the Society for Experimental Biology. Chromosome Organization and Cytogenomics, 30 June - 3 July 2010, Prague, Czech Republic

  6. Kolesnikov NN. X-chromosome inactivation, mobile elements and ncRNA genes. 6th International Conference on Bioinformatics of Genome Regulation and Structure, 22-28 June 2008, Novosibirsk, Russia

  7. Kolesnikov NN. Evolution of the structure of the XIST locus in mammals. 5th International Conference on Bioinformatics of Genome Regulation and Structure, 16-22 July 2006, Novosibirsk, Russia

Collaboration: 
  • Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung, Gatersleben, Germany

  • Institute of Experimental Botany, Olomouc, Czech Republic

  • Institute of Genetics and Cytology, Minsk, Belarus

  • John Innes Centre, Norwich, UK