Department of Regulation of Genetic Processes

Laboratory of Cell Division

Omelina Evgeniya
head

Staff: 
thomson_logo.gif scopus_logo.jpg Omelina Evgeniya head PhD (Biology) omelinaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Andreyeva Evgeniya senior research fellow PhD (Biology) andreevaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Ogienko Anna senior research fellow PhD (Biology) ogienko [dot] annaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Galimova Juliya senior research fellow PhD (Biology) galimovaatmcb [dot] nsc [dot] ru
      Battulina Nadezhda research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg Dubatolova Tatiana research fellow   tdubatatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Letiagina Anna research assistant   leschenko [dot] annaatmcb [dot] nsc [dot] ru
  scopus_logo.jpg   Volegov Grigory research assistant    
  scopus_logo.jpg   Motorina Daria research assistant    
      Korepina Maria research assistant    
      Surkova Elina research assistant    
      Lepekhina Tatiana lab technician    
thomson_logo.gif scopus_logo.jpg Kozhevnikova Elena part-time senior research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg Boldyreva Lidiya part-time senior research fellow PhD (Biology) asdatmcb [dot] nsc [dot] ru
  scopus_logo.jpg   Morozova Maryana part-time research fellow PhD (Biology)  
  scopus_logo.jpg   Achasova Kseniya part-time junior research fellow    
thomson_logo.gif scopus_logo.jpg Popova Julia part-time junior research fellow   popovaatmcb [dot] nsc [dot] ru
  scopus_logo.jpg   Sajdakova Snezhanna part-time junior research fellow    
      Fakhrutdinova Alena part-time lab technician    

Former research workers:

Anders (Munzarova) Alina
Ivankin Anton
Ivankina (Zotkevich) Elena
Fedorova Yulia
Kiseleva Elena, PhD
Kopyl Sergei, PhD
Lebedev Mikhail
Lebedeva Lidia, DSc
Maltseva Svetlana		 Mursalimov Sergey, PhD
Oshchepkova (Alekseyeva) Anastasia
Pavlova Gera, PhD
Pindyurin Alexey, PhD
Razuvaeva Alena
Sherstobitova Natalia
Strunov Anton, PhD
Yarinich Lyubov
Yushkova Anastasiya

BDGP_logo.jpg

The staff of the Laboratory are among the contributors of Release 6 reference sequence of the Drosophila melanogaster genome
Recent publications: 

  1. Razuvaeva AV, Graziadio L, Palumbo V, Pavlova GA, Popova JV, Pindyurin AV, Bonaccorsi S, Somma MP, Gatti M. The multiple mitotic roles of the ASPM orthologous proteins: Insight into the etiology of ASPM-dependent microcephaly. (doi: 10.3390/cells12060922) Cells 12(6): 922, 2023

  2. Omelina ES, Letiagina AE, Boldyreva LV, Ogienko AA, Galimova YA, Yarinich LA, Pindyurin AV, Andreyeva EN. Slight variations in the sequence downstream of the polyadenylation signal significantly increase transgene expression in HEK293T and CHO cells. (doi: 10.3390/ijms232415485) Int J Mol Sci 23(24): 15485, 2022

  3. Fishman V, Pindyurin AV. Editorial: The role of high-order chromatin organization in gene regulation. (doi: 10.3389/fgene.2022.1045787) Front Genet 13: 1045787, 2022

  4. Morozova MV, Borisova MA, Snytnikova OA, Achasova KM, Litvinova EA, Tsentalovich YuP, Kozhevnikova EN. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. (doi: 10.1038/s41598-022-19219-z) Sci Rep 12: 16345, 2022

  5. Ogienko AA, Omelina ES, Bylino OV, Batin MA, Georgiev PG, Pindyurin AV. Drosophila as a model organism to study basic mechanisms of longevity. (doi: 10.3390/ijms231911244) Int J Mol Sci 23(19): 11244, 2022

  6. Morgacheva D, Daks A, Smirnova A, Kim A, Ryzhkova D, Mitrofanova L, Staliarova A, Omelina E, Pindyurin A, Fedorova O, Shuvalov O, Petukhov A, Dinikina Yu. Case report: Primary leptomeningeal medulloblastoma in a child: Clinical case report and literature review. (doi: 10.3389/fped.2022.925340) Front Pediatr 10: 925340, 2022

  7. Popova JV, Pavlova GA, Razuvaeva AV, Yarinich LA, Andreyeva EN, Anders AF, Galimova YA, Renda F, Somma MP, Pindyurin AV, Gatti M. Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis. (doi: 10.3390/cells11142127) Cells 11(14): 2127, 2022

  8. Dubatolova TD, Ritter GS, Proskurina AS, Kisaretova PE, Nikolin VP, Popova NA, Ruzanova VS, Taranov OS, Kolchanov NA, Bogachev SS. Changes in the number and morphology of blood cells in mice pretreated with RNA preparations and exposed to 8 Gy of gamma radiation. (doi: 10.52547/ijrr.20.2.16) Int J Rad Res 20(2): 361-368, 2022

  9. Boldyreva LV, Andreyeva EN, Pindyurin AV. Position effect variegation: Role of the local chromatin context in gene expression regulation. (doi: 10.1134/S0026893322030049) Mol Biology (Moscow) 56: 307-338, 2022

  10. Bets VD, Achasova KM, Borisova MA, Kozhevnikova EN, Litvinova EA. Role of Mucin 2 glycoprotein and L-fucose in interaction of immunity and microbiome within the experimental model of inflammatory bowel disease. (doi: 10.1134/S0006297922040010) Biochemistry (Moscow) 87(4): 301-318, 2022

  11. Strunov A, Boldyreva LV, Pindyurin AV, Gatti M, Kiseleva E. TEM imaging of membrane choreography during mitosis of Drosophila tissue culture cells. In: "The Nuclear Pore Complex" (Goldberg MW Ed.), Humana Press, pp 407-415, 2022 (doi: 10.1007/978-1-0716-2337-4)

  12. Ilyin AA, Kononkova AD, Golova AV, Shloma VV, Olenkina OM, Nenasheva VV, Abramov YuA, Kotov AA, Maksimov DA, Laktionov PP, Pindyurin AV, Galitsyna AA, Ulianov SV, Khrameeva EE, Gelfand MS, Belyakin SN, Razin SV, Shevelyov YuY. Comparison of genome architecture at two stages of male germline cell differentiation in Drosophila. (doi: 10.1093/nar/gkac109) Nucleic Acids Res  50(6): 3203–3225, 2022

  13. Ogienko AG, Myz SA, Nefedov AA, Ogienko AA, Adamova TP, Voronkova OM, Amosova SV, Trofimov BA, Boldyrev VV, Boldyreva EV. Clathrate hydrates of organic solvents as auxiliary intermediates in pharmaceutical research and development: improving dissolution behaviour of a new anti-tuberculosis drug, Perchlozon. (doi: 10.3390/pharmaceutics14030495) Pharmaceutics 14(3): 495, 2022

  14. Omelina ES, Yushkova AA, Motorina DM, Volegov GA, Kozhevnikova EN, Pindyurin AV. Optogenetic and chemical induction systems for regulation of transgene expression in plants: use in basic and applied research. (doi: 10.3390/ijms23031737) Int J Mol Sci 23(3): 1737, 2022

  15. Boldyreva LV, Morozova MV, Saydakova SS, Kozhevnikova EN. Fat of the gut: epithelial phospholipids in inflammatory bowel diseases. (doi: 10.3390/ijms222111682) Int J Mol Sci 22(21): 11682, 2021

  16. Zykova T, Maltseva M, Goncharov F, Boldyreva L, Pokholkova G, Kolesnikova T, Zhimulev I. The organization of pericentromeric heterochromatin in polytene chromosome 3 of the Drosophila melanogaster line with the Rif11; SuURES Su(var)3-906 mutations suppressing underreplication. (doi: 10.3390/cells10112809) Cells 10(11): 2809, 2021

  17. Achasova KM, Kozhevnikova EN, Borisova MA, Litvinova EA. Fucose ameliorates Tritrichomonas sp.-associated illness in tntibiotic-treated Muc2−/− mice. (doi: 10.3390/ijms221910699) Int J Mol Sci 22(19): 10699, 2021

  18. Dolgova EV, ... Dubatolova TD, ... Bogachev SS. Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma. (doi: 10.20892/j.issn.2095-3941.2020.0511) Cancer Biol Med 18(3): 910-930, 2021

  19. Letiagina AE, Omelina ES, Ivankin AV, Pindyurin AV. MPRAdecoder: processing of the raw MPRA data with a priori unknown sequences of the region of interest and associated barcodes. (doi: 10.3389/fgene.2021.618189) Front Genet 12: 618189, 2021

  20. Litvinova EA, Bets VD, Feofanova NA, Gvozdeva OV, Achasova KM, Alperina EL, Kozhevnikova EN. Dietary fucose affects macrophage polarization and reproductive performance in mice. (doi: 10.3390/nu13030855) Nutrients 13(3): 855, 2021

  21. Boldyreva LV, Yarinich LA, Kozhevnikova EN, Ivankin AV, Lebedev MO, Pindyurin AV. Fine gene expression regulation by minor sequence variations downstream of the polyadenylation signal.(doi: 10.1007/s11033-021-06160-z) Mol Biol Rep 48: 1539-1547, 2021

  22. Dolskiy AA, Yarushkin AA, Grishchenko IV, Lemskaya NA, Pindyurin AV, Boldyreva LV, Pustylnyak VO, Yudkin DV. miRNA expression and interaction with the 3′UTR of FMR1 in FRAXopathy pathogenesis. (doi: 10.1016/j.ncrna.2020.11.006) Non-coding RNA Res 6(1): 1-7, 2021

  23. Borisova MA, Achasova KM, Morozova KN, Andreyeva EN, Litvinova EA, Ogienko AA, Morozova MV, Berkaeva MB, Kiseleva E, Kozhevnikova EN. Mucin-2 knockout is a model of intercellular junction defects, mitochondrial damage and ATP depletion in the intestinal epithelium. (doi: 10.1038/s41598-020-78141-4) Sci Rep 10: 21135, 2020

  24. Dorogova NV, Galimova YA, Bolobolova EU, Baricheva EM, Fedorova SA. Loss of Drosophila E3 ubiquitin ligase Hyd promotes extra mitosis in germline cysts and massive cell death during oogenesis. (doi: 10.3389/fcell.2020.600868) Front Cell Dev Biol 8: 600868, 2020

  25. Ogienko AA, Andreyeva EN, Omelina ES, Oshchepkova AL, Pindyurin AV. Molecular and cytological analysis of widely-used Gal4 driver lines for Drosophila neurobiology. (doi: 10.1186/s12863-020-00895-7) BMC Genetics 21: 96, 2020

  26. Ogienko AA, Yarinich LA, Fedorova EV, Dorogova NV, Bayborodin SI, Baricheva EM, Pindyurin AV. GAGA regulates border cell migration in Drosophila. (doi: 10.3390/ijms21207468) Int J Mol Sci 21(20): 7468, 2020

  27. Ritter GS, Nikolin VP, Popova NA, Proskurina AS, Kisaretova PE, Taranov OS, Dubatolova TD, Dolgova EV, Potter EA, Kirikovich SS, Efremov YaR, Bayborodin SI, Romanenko MV, Meschaninova MI, Venyaminova AG, Kolchanov NA, Shurdov MA, Bogachev SS. Characterization of biological peculiarities of the radioprotective activity of double-stranded RNA isolated from Saccharomyces сerevisiae. (doi: 10.1080/09553002.2020.1793020) Int J Radiat Biol 96(9): 1173-1191, 2020

  28. Somma MP, Andreyeva EN, Pavlova GA, Pellacani C, Bucciarelli E, Popova JV, Bonaccorsi S, Pindyurin AV, Gatti M. Moonlighting in mitosis: analysis of the mitotic functions of transcription and splicing factors. (doi: 10.3390/cells9061554) Cells 9(6): 1554, 2020

  29. Kisaretova PE, Kirikovich SS, Ritter GS, Efremov YR, Taranov OS, Dubatolova TD, Proskurina AS, Potter EA, Dolgova EV, Sidorov SV, Ostanin AA, Chernych ER, Bogachev SS. Approbation of the cancer treatment approach based on the eradication of TAMRA+ cancer stem cells in a model of murine cyclophosphamide resistant lymphosarcoma. (doi: 10.21873/anticanres.14011) Anticancer Res 40(2): 795-805, 2020

  30. Demakova OV, Demakov SA, Boldyreva LV, Zykova TYu, Levitsky VG, Semeshin VF, Pokholkova GV, Sidorenko DS, Goncharov FP, Belyaeva ES, Zhimulev IF. Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes. (doi: 10.1007/s00412-019-00728-2) Chromosoma 129(1): 25-44, 2020

  31. Borisova MA, Snytnikova OA, Litvinova EA, Achasova KM, Babochkina TI, Pindyurin AV, Tsentalovich YuP, Kozhevnikova EN. Fucose ameliorates tryptophan metabolism and behavioral abnormalities in a mouse model of chronic colitis. (doi: 10.3390/nu12020445) Nutrients 12(2): 445, 2020

  32. Ogienko AG, Stoporev AS, Ogienko AA, Mel'gunov MS, Adamova TP, Yunoshev AS, Manakov AY, Boldyreva EV. Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying. (doi: 10.1039/c9cc00397e) Chem Commun 55(29): 4262-4265, 2019

  33. Pavlova GA, Popova JV, Andreyeva EN, Yarinich LA, Lebedev MO, Razuvaeva AV, Dubatolova TD, Oshchepkova AL, Pellacani C, Somma MP, Pindyurin AV, Gatti M. RNAi-mediated depletion of the NSL complex subunits leads to abnormal chromosome segregation and defective centrosome duplication in Drosophila mitosis. (doi: 10.1371/journal.pgen.1008371) PLoS Genet 15(9): e1008371, 2019

  34. Omelina ES, Ivankin AV, Letiagina AE, Pindyurin AV. Optimized PCR conditions minimizing the formation of chimeric DNA molecules from MPRA plasmid libraries. (doi: 10.1186/s12864-019-5847-2) BMC Genomics 20 (Suppl 7): 536, 2019

  35. Pavlova GA, Razuvaeva AV, Popova JV, Andreyeva EN, Yarinich LA, Lebedev MO, Pellacani C, Bonaccorsi S, Somma MP, Gatti M, Pindyurin AV. The role of Patronin in Drosophila mitosis. (doi: 10.1186/s12860-019-0189-0) BMC Mol Cell Biol 20 (Suppl 1): 7, 2019

  36. Gisler S, Gonçalves JP, Akhtar W, de Jong J, Pindyurin AV, Wessels LFA, van Lohuizen M. Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency. (doi: 10.1038/s41467-019-09551-w) Nature Communications 10: 1598, 2019

  37. Omelina ES, Pindyurin AV. Optogenetic regulation of endogenous gene transcription in mammals. (doi: 10.18699/VJ19.485) Vavilov J Genetics Breeding 23(2): 219-225, 2019

  38. Lebedev MO, Yarinich LA, Ivankin AV, Pindyurin AV. Generation of barcoded plasmid libraries for massively parallel analysis of chromatin position effects. (doi: 10.18699/VJ19.483) Vavilov J Genetics Breeding 23(2): 203-211, 2019

  39. Andreyeva EN, Ogienko AA, Yushkova AA, Popova JV, Pavlova GA, Kozhevnikova EN, Ivankin AV, Gatti M, Pindyurin AV. Non3 is an essential Drosophila gene required for proper nucleolus assembly. (doi: 10.18699/VJ19.481) Vavilov J Genetics Breeding 23(2): 190-198, 2019

  40. Andreyeva EN, Ogienko AA, Dubatolova TD, Oshchepkova AL, Kozhevnikova EN, Ivankin AV, Pavlova GA, Kopyl SA, Pindyurin AV. A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism. (doi: 10.1186/s12863-019-0726-z) BMC Genetics 20(Suppl 1): 31, 2019

  41. Fedorova EV, Dorogova NV, Bolobolova EU, Fedorova SA, Karagodin DA, Ogienko AA, Khruscheva AS, Baricheva EM. GAGA protein is required for multiple aspects of Drosophila oogenesis and female fertility. (doi: 10.1002/dvg.23269) Genesis 57(2): e23269, 2019 

  42. Ogienko AG, Markov AV, Sen'kova AV, Logashenko EB, Salomatina OV, Myz SA, Ogienko AA, Nefedov AA, Losev EA, Drebushchak TN, Salakhutdinov NF, Boldyrev VV, Vlasov VV, Zenkova MA, Boldyreva EV. Increasing bioavailability of very poorly water-soluble compounds. A case study of an anti-tumor drug, soloxolon methyl. (doi: 10.1016/j.jddst.2018.10.025) J Drug Delivery Sci Tech 49: 35-42, 2019

Publications for previous years

Selected talks: 

  1. Pavlova G. The role of Drosophila NSL complex in centromere/kinetochore assembly. 14th International conference on Drosophila heterochromatin, 9-15 June 2019, Spoleto, Italy

  2. Pindyurin AV. Input of DNA sequences located in the transcription termination region in gene expression level. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  3. Ogienko AA. The influence of genetic background in Drosophila fly lines on results on example of line №6458 from Bloomington Drosophila Stock Center. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  4. Pavlova GA. Roles of Drosophila NSL complex components in mitosis. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  5. Popova JV. The moonlighting functions of the NON3 protein in Drosophila melanogaster. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  6. Andreyeva EN. The CG17337 protein is involved in mitosis progression and control the cell death in Drosophila melanogaster. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  7. Andreyeva E. Functional characterization of the conservative protein CG17337 in Drosophila melanogaster. International mini-conference “Chromosomes and mitosis – 2017”, December 8, 2017, Novosibirsk

  8. Pindyurin A. Large fraction of heterochromatin in Drosophila neurons is simultaneously bound by B-type lamin and HP1a. International mini-conference “Chromosomes and mitosis – 2017”, December 8, 2017, Novosibirsk

  9. Pindyurin A. Efficient delivery of transgenes to cultured Drosophila cells. 13th International conference on Drosophila heterochromatin, June 4-10, 2017, Cagliari, Italy

  10. Pindyurin AV. Cell type-specific mapping of genomic binding sites of chromatin proteins using FLP-inducible DamID systems in Drosophila. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  11. Boldyreva LV. A point deletion in a region immediately downstream of GFP reporter 3′ UTR increases level of GFP transcription in mouse and human cells two-fold. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  12. Yarinich LA. Adaptation of the piggyBac transposon system to study position effects in cultured Drosophila cells. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  13. Munzarova AF. Measuring microtubule flux using the modification of a standard photobleaching-based method. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  14. Razuvaeva AV. Analysis of the involvement of kinesin-like proteins in cell division of Drosophila S2 cells. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  15. Popova JV. Role of Eb1, Mars, Mast and Mei-38 proteins in kinetochore-driven microtubule growth in Drosophila S2 cells. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  16. Pavlova GA. Role of the minus-end binding proteins in kinetochore-driven microtubule growth. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  17. Pindyurin AV. A TRIP through the genome: a high-throughput method to study the influence of chromatin context on gene regulation. 10th Dutch Chromatin Meeting. 24 October 2012, Amsterdam, Netherlands

  18. Andreyeva EN. The SUUR protein affects late replicating chromatin domains in Drosophila melanogaster. Meeting on Eukaryotic DNA replication and genome maintenance, 5-9 September 2007, Cold Spring Harbor, New York, USA

Collaboration: 

  • Università di Roma “Sapienza”, Roma, Italy 

  • The Netherlands Cancer Institute, Amsterdam, Netherlands

  • Ludwig-Maximilians-University Munich, Germany

  • Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

  • Albert Einstein College of Medicine, New York, NY, USA

  • Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA 

  • Massachusetts Institute of Technology, Cambridge, MA, USA 

  • Department of Molecular Biology, Umeå University, Umeå, Sweden

Research Groups

Department of Structure and Function of Chromosomes
Department of Diversity and Evolution of Genomes
Department of Regulation of Genetic Processes