Department of Regulation of Genetic Processes

Laboratory of Cell Division

Omelina Evgeniya
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Omelina Evgeniya head PhD (Biology) omelinaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Andreyeva Evgeniya senior research fellow PhD (Biology) andreevaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Ogienko Anna senior research fellow PhD (Biology) ogienko [dot] annaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Galimova Juliya senior research fellow PhD (Biology) galimovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Klimova Natalya senior research fellow PhD (Biology) klimovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Battulina Nadezhda research fellow PhD (Biology) battulinaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Dubatolova Tatiana research fellow   tdubatatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Letiagina Anna research fellow   leschenko [dot] annaatmcb [dot] nsc [dot] ru
      Surkova Elina research assistant    
      Posazhennikov Makar research assistant    
      Shevchenko Alexey research assistant    
      Lepekhina Tatiana lab technician    
thomson_logo.gif scopus_logo.jpg Boldyreva Lidiya part-time senior research fellow PhD (Biology) asdatmcb [dot] nsc [dot] ru
      Zagorskaya Alla part-time research fellow    
      Fakhrutdinova Alena part-time lab technician    

Former research workers:

Achasova Kseniya
Anders (Munzarova) Alina
Andreyeva Elizaveta
Ivankin Anton
Ivankina (Zotkevich) Elena
Fedorova Yulia
Kiseleva Elena, PhD
Kopyl Sergei, PhD
Korepina Maria
Kozhevnikova Elena, PhD
Lebedev Mikhail
Lebedeva Lidia, DSc
Maltseva Svetlana
Medvedeva (Sajdakova) Snezhanna		 Morozova Maryana, PhD
Motorina Daria
Mursalimov Sergey, PhD
Nikelvart Ekaterina
Oshchepkova (Alekseyeva) Anastasia
Pavlova Gera, PhD
Pindyurin Alexey, PhD
Popova Julia, PhD
Razuvaeva Alena
Sherstobitova Natalia
Strunov Anton, PhD
Volegov Grigory
Yarinich Lyubov
Yushkova Anastasiya

BDGP_logo.jpg

The staff of the Laboratory are among the contributors of Release 6 reference sequence of the Drosophila melanogaster genome
Recent publications: 

  1. Medvedeva S, Achasova K, Boldyreva L, Ogienko A, Kozhevnikova E. The application of explants, crypts, and organoids as models in intestinal barrier research. Tissue Barriers, 2024, doi: 10.1080/21688370.2024.2423137

  2. Ogienko AA, Andreyeva EN, Yarinich LA, Pindyurin AV, Battulina NV, Omelina ES. Expression pattern of the AB1-Gal4 driver in Drosophila third-instar larvae. (doi: 10.3390/ijms26093923) Int J Mol Sci 26(9): 3923, 2025

  3. Popova JV, Bets VD, Omelina ES, Boldyreva LV, Kozhevnikova EN. Adapting mouse genome editing technique from scratch using in utero electroporation. (doi: 10.1134/S0026893324060098) Mol Biol 58(6): 1312-1320, 2024

  4. Ruzanova VS, Kirikovich SS, Levites EV, Proskurina AS, Dolgova EV, Ritter GS, Efremov YR, Dubatolova TD, Sysoev AV, Koleno DI, Ostanin AA, Chernykh ER, Bogachev SS. The macrophage activator GcMAF-RF enhances the antitumor effect of Karanahan technology through induction of M2-M1 macrophage reprogramming. (doi: 10.1155/2024/7484490) J Immunol Res 2024: 7484490, 2024

  5. Motorina DM, Galimova YA, Battulina NV, Omelina ES. Systems for targeted silencing of gene expression and their application in plants and animals. (doi: 10.3390/ijms25105231) Int J Mol Sci 25(10): 5231, 2024

  6. Bylino OV, Ogienko AA, Batin MA, Georgiev PG, Omelina ES. Genetic, environmental, and stochastic components of lifespan variability: The Drosophila paradigm. (doi: 10.3390/ijms25084482) Int J Mol Sci 25(8): 4482, 2024

  7. Ogienko AA, Korepina MO, Pindyurin AV, Omelina ES. New functional motifs for the targeted localization of proteins to the nucleolus in Drosophila and human cells. (doi: 10.3390/ijms25021230) Int J Mol Sci 25(2): 1230, 2024

  8. Saydakova S, Morozova K, Snytnikova O, Morozova M, Boldyreva L, Kiseleva E, Tsentalovich Y, Kozhevnikova E. The effect of dietary phospholipids on the ultrastructure and function of intestinal epithelial cells. (doi: 10.3390/ijms24021788) Int J Mol Sci 24(2): 1788, 2023

  9. Lubyaga Yu, Yarinich L, Drozdova P, Pindyurin A, Gurkov A, Luckenbach T, Timofeyev M. The ABCs of the amphipod P-glycoprotein: Heterologous production of the Abcb1 protein of a model species Eulimnogammarus verrucosus (Amphipoda: Gammaridae) from Lake Baikal. (doi: 10.1016/j.cbpc.2023.109677) Comp Biochem Physiol C Toxicol Pharmacol 271: 109677, 2023

  10. Razuvaeva AV, Graziadio L, Palumbo V, Pavlova GA, Popova JV, Pindyurin AV, Bonaccorsi S, Somma MP, Gatti M. The multiple mitotic roles of the ASPM orthologous proteins: Insight into the etiology of ASPM-dependent microcephaly. (doi: 10.3390/cells12060922) Cells 12(6): 922, 2023

  11. Omelina ES, Letiagina AE, Boldyreva LV, Ogienko AA, Galimova YA, Yarinich LA, Pindyurin AV, Andreyeva EN. Slight variations in the sequence downstream of the polyadenylation signal significantly increase transgene expression in HEK293T and CHO cells. (doi: 10.3390/ijms232415485) Int J Mol Sci 23(24): 15485, 2022

  12. Fishman V, Pindyurin AV. Editorial: The role of high-order chromatin organization in gene regulation. (doi: 10.3389/fgene.2022.1045787) Front Genet 13: 1045787, 2022

  13. Morozova MV, Borisova MA, Snytnikova OA, Achasova KM, Litvinova EA, Tsentalovich YuP, Kozhevnikova EN. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. (doi: 10.1038/s41598-022-19219-z) Sci Rep 12: 16345, 2022

  14. Ogienko AA, Omelina ES, Bylino OV, Batin MA, Georgiev PG, Pindyurin AV. Drosophila as a model organism to study basic mechanisms of longevity. (doi: 10.3390/ijms231911244) Int J Mol Sci 23(19): 11244, 2022

  15. Morgacheva D, Daks A, Smirnova A, Kim A, Ryzhkova D, Mitrofanova L, Staliarova A, Omelina E, Pindyurin A, Fedorova O, Shuvalov O, Petukhov A, Dinikina Yu. Case report: Primary leptomeningeal medulloblastoma in a child: Clinical case report and literature review. (doi: 10.3389/fped.2022.925340) Front Pediatr 10: 925340, 2022

  16. Popova JV, Pavlova GA, Razuvaeva AV, Yarinich LA, Andreyeva EN, Anders AF, Galimova YA, Renda F, Somma MP, Pindyurin AV, Gatti M. Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis. (doi: 10.3390/cells11142127) Cells 11(14): 2127, 2022

  17. Dubatolova TD, Ritter GS, Proskurina AS, Kisaretova PE, Nikolin VP, Popova NA, Ruzanova VS, Taranov OS, Kolchanov NA, Bogachev SS. Changes in the number and morphology of blood cells in mice pretreated with RNA preparations and exposed to 8 Gy of gamma radiation. (doi: 10.52547/ijrr.20.2.16) Int J Rad Res 20(2): 361-368, 2022

  18. Boldyreva LV, Andreyeva EN, Pindyurin AV. Position effect variegation: Role of the local chromatin context in gene expression regulation. (doi: 10.1134/S0026893322030049) Mol Biology (Moscow) 56: 307-338, 2022

  19. Bets VD, Achasova KM, Borisova MA, Kozhevnikova EN, Litvinova EA. Role of Mucin 2 glycoprotein and L-fucose in interaction of immunity and microbiome within the experimental model of inflammatory bowel disease. (doi: 10.1134/S0006297922040010) Biochemistry (Moscow) 87(4): 301-318, 2022

  20. Strunov A, Boldyreva LV, Pindyurin AV, Gatti M, Kiseleva E. TEM imaging of membrane choreography during mitosis of Drosophila tissue culture cells. In: "The Nuclear Pore Complex" (Goldberg MW Ed.), Humana Press, pp 407-415, 2022 (doi: 10.1007/978-1-0716-2337-4)

  21. Ilyin AA, Kononkova AD, Golova AV, Shloma VV, Olenkina OM, Nenasheva VV, Abramov YuA, Kotov AA, Maksimov DA, Laktionov PP, Pindyurin AV, Galitsyna AA, Ulianov SV, Khrameeva EE, Gelfand MS, Belyakin SN, Razin SV, Shevelyov YuY. Comparison of genome architecture at two stages of male germline cell differentiation in Drosophila. (doi: 10.1093/nar/gkac109) Nucleic Acids Res  50(6): 3203–3225, 2022

  22. Ogienko AG, Myz SA, Nefedov AA, Ogienko AA, Adamova TP, Voronkova OM, Amosova SV, Trofimov BA, Boldyrev VV, Boldyreva EV. Clathrate hydrates of organic solvents as auxiliary intermediates in pharmaceutical research and development: improving dissolution behaviour of a new anti-tuberculosis drug, Perchlozon. (doi: 10.3390/pharmaceutics14030495) Pharmaceutics 14(3): 495, 2022

  23. Omelina ES, Yushkova AA, Motorina DM, Volegov GA, Kozhevnikova EN, Pindyurin AV. Optogenetic and chemical induction systems for regulation of transgene expression in plants: use in basic and applied research. (doi: 10.3390/ijms23031737) Int J Mol Sci 23(3): 1737, 2022

  24. Boldyreva LV, Morozova MV, Saydakova SS, Kozhevnikova EN. Fat of the gut: epithelial phospholipids in inflammatory bowel diseases. (doi: 10.3390/ijms222111682) Int J Mol Sci 22(21): 11682, 2021

  25. Zykova T, Maltseva M, Goncharov F, Boldyreva L, Pokholkova G, Kolesnikova T, Zhimulev I. The organization of pericentromeric heterochromatin in polytene chromosome 3 of the Drosophila melanogaster line with the Rif11; SuURES Su(var)3-906 mutations suppressing underreplication. (doi: 10.3390/cells10112809) Cells 10(11): 2809, 2021

  26. Achasova KM, Kozhevnikova EN, Borisova MA, Litvinova EA. Fucose ameliorates Tritrichomonas sp.-associated illness in tntibiotic-treated Muc2−/− mice. (doi: 10.3390/ijms221910699) Int J Mol Sci 22(19): 10699, 2021

  27. Dolgova EV, ... Dubatolova TD, ... Bogachev SS. Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma. (doi: 10.20892/j.issn.2095-3941.2020.0511) Cancer Biol Med 18(3): 910-930, 2021

  28. Letiagina AE, Omelina ES, Ivankin AV, Pindyurin AV. MPRAdecoder: processing of the raw MPRA data with a priori unknown sequences of the region of interest and associated barcodes. (doi: 10.3389/fgene.2021.618189) Front Genet 12: 618189, 2021

  29. Litvinova EA, Bets VD, Feofanova NA, Gvozdeva OV, Achasova KM, Alperina EL, Kozhevnikova EN. Dietary fucose affects macrophage polarization and reproductive performance in mice. (doi: 10.3390/nu13030855) Nutrients 13(3): 855, 2021

  30. Boldyreva LV, Yarinich LA, Kozhevnikova EN, Ivankin AV, Lebedev MO, Pindyurin AV. Fine gene expression regulation by minor sequence variations downstream of the polyadenylation signal.(doi: 10.1007/s11033-021-06160-z) Mol Biol Rep 48: 1539-1547, 2021

  31. Dolskiy AA, Yarushkin AA, Grishchenko IV, Lemskaya NA, Pindyurin AV, Boldyreva LV, Pustylnyak VO, Yudkin DV. miRNA expression and interaction with the 3′UTR of FMR1 in FRAXopathy pathogenesis. (doi: 10.1016/j.ncrna.2020.11.006) Non-coding RNA Res 6(1): 1-7, 2021

Publications for previous years

Selected talks: 

  1. Pavlova G. The role of Drosophila NSL complex in centromere/kinetochore assembly. 14th International conference on Drosophila heterochromatin, 9-15 June 2019, Spoleto, Italy

  2. Pindyurin AV. Input of DNA sequences located in the transcription termination region in gene expression level. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  3. Ogienko AA. The influence of genetic background in Drosophila fly lines on results on example of line №6458 from Bloomington Drosophila Stock Center. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  4. Pavlova GA. Roles of Drosophila NSL complex components in mitosis. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  5. Popova JV. The moonlighting functions of the NON3 protein in Drosophila melanogaster. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  6. Andreyeva EN. The CG17337 protein is involved in mitosis progression and control the cell death in Drosophila melanogaster. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  7. Andreyeva E. Functional characterization of the conservative protein CG17337 in Drosophila melanogaster. International mini-conference “Chromosomes and mitosis – 2017”, December 8, 2017, Novosibirsk

  8. Pindyurin A. Large fraction of heterochromatin in Drosophila neurons is simultaneously bound by B-type lamin and HP1a. International mini-conference “Chromosomes and mitosis – 2017”, December 8, 2017, Novosibirsk

  9. Pindyurin A. Efficient delivery of transgenes to cultured Drosophila cells. 13th International conference on Drosophila heterochromatin, June 4-10, 2017, Cagliari, Italy

  10. Pindyurin AV. Cell type-specific mapping of genomic binding sites of chromatin proteins using FLP-inducible DamID systems in Drosophila. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  11. Boldyreva LV. A point deletion in a region immediately downstream of GFP reporter 3′ UTR increases level of GFP transcription in mouse and human cells two-fold. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  12. Yarinich LA. Adaptation of the piggyBac transposon system to study position effects in cultured Drosophila cells. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  13. Munzarova AF. Measuring microtubule flux using the modification of a standard photobleaching-based method. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  14. Razuvaeva AV. Analysis of the involvement of kinesin-like proteins in cell division of Drosophila S2 cells. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  15. Popova JV. Role of Eb1, Mars, Mast and Mei-38 proteins in kinetochore-driven microtubule growth in Drosophila S2 cells. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  16. Pavlova GA. Role of the minus-end binding proteins in kinetochore-driven microtubule growth. International mini-conference "Chromosomes and Mitosis – 2016", November 25, 2016, Novosibirsk

  17. Pindyurin AV. A TRIP through the genome: a high-throughput method to study the influence of chromatin context on gene regulation. 10th Dutch Chromatin Meeting. 24 October 2012, Amsterdam, Netherlands

  18. Andreyeva EN. The SUUR protein affects late replicating chromatin domains in Drosophila melanogaster. Meeting on Eukaryotic DNA replication and genome maintenance, 5-9 September 2007, Cold Spring Harbor, New York, USA

Collaboration: 

  • Università di Roma “Sapienza”, Roma, Italy 

  • The Netherlands Cancer Institute, Amsterdam, Netherlands

  • Ludwig-Maximilians-University Munich, Germany

  • Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

  • Albert Einstein College of Medicine, New York, NY, USA

  • Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA 

  • Massachusetts Institute of Technology, Cambridge, MA, USA 

  • Department of Molecular Biology, Umeå University, Umeå, Sweden

Research Groups

Department of Structure and Function of Chromosomes
Department of Regulation of Genetic Processes