Department of Molecular Immunology

Laboratory of Preclinical Research

Chikaev Anton
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Chikaev Anton head PhD (Biology) chikaevatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Gorchakov Andrey senior research fellow PhD (Biology) gorchakovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Popova Julia research fellow PhD (Biology) popovaatmcb [dot] nsc [dot] ru
      Zybkina Anastassia research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg   Medvedeva Snezhanna junior research fellow PhD (Biology) medvedevaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Solodkov Pavel junior research fellow   solodkov [dot] pavelatmcb [dot] nsc [dot] ru
      Desyukevich Pavel junior research fellow    
      Mukhametdinova Victoria research assistant    
      Andrejeva Jelizaveta research assistant   andreeva [dot] eatmcb [dot] nsc [dot] ru
      Nikelvart Ekaterina research assistant   nikelvartatmcb [dot] nsc [dot] ru
      Zholnirovskaya Maria research assistant    

Research: 

The laboratory conducts fundamental and applied research aimed at developing highly specific protein molecules for the diagnosis and treatment of oncological and infectious diseases. Key objectives include:

  • Developing novel anti-tumor and virus-neutralizing antibodies, as well as engineering bispecific antibodies (BiTEs) and chimeric antigen receptors (CARs) based on these molecules for T-cell therapy;
  • Developing three-dimensional organoid models of the intestine and lungs to study the molecular and cellular mechanisms of disease and to conduct preclinical evaluations of the efficacy and safety of therapeutic agents;
  • Creating domestically produced reagents for organoid culture to expand the experimental infrastructure available for preclinical research.