Department of the Diversity and Evolution of Genomes

Laboratory of Animal Cytogenetics

Graphodatsky Alexander
Head of the Department
Head of the Laboratory

Staff: 
      Name Position Academic
degree
Contacts
thomson_logo.gif scopus_logo.jpg Graphodatsky Alexander head DSc (Biology) grafatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Perelman Polina leading research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg Romanenko Svetlana senior research fellow PhD (Biology) rosaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpgscopus_logo.jpgscopus_logo.jpg Kulemzina (Nesterenko) Anastasia research fellow PhD (Biology) zakalatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpgscopus_logo.jpgscopus_logo.jpg Serdyukova Natalia research fellow    
thomson_logo.gif scopus_logo.jpg Druzhkova Anna junior research fellow   radaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Makunin Alexey junior research fellow PhD (Biology)  
thomson_logo.gif scopus_logo.jpg Gladkikh Olga junior research fellow    
thomson_logo.gif scopus_logo.jpg   Proskuryakova Anastasia research assistant    
      Kusliy Maria research assistant    
      Butakova Yulia lab technician    

Recent publications: 
  1. Kolesnikova IS, Dolskiy AA, Lemskaya NA, Maksimova YuV, Shorina AR, Graphodatsky AS, Galanina EM, Yudkin DV. Alteration of rRNA gene copy number and expression in patients with intellectual disability and heteromorphic acrocentric chromosomes. Egypt J Med Hum Genet, 2017, doi: 10.1016/j.ejmhg.2017.08.010

  2. Telepova AS, Romanenko SA, Lemskaya NA, Maksimova YuV, Shorina AR, Yudkin DV. X-derived marker chromosome in patient with mosaic Turner syndrome and Dandy-Walker syndrome: a case report. Mol Cytogenet 10: 43, 2017

  3. Andreyushkova DA, Makunin AI, Beklemisheva VR, Romanenko SA, Druzhkova AS, Biltueva LB, Serdyukova NA, Graphodatsky AS, Trifonov VA. Next generation sequencing of chromosome-specific libraries sheds light on genome evolution in paleotetraploid sterlet (Acipenser ruthenus). Genes 8(11): 318, 2017

  4. Biltueva LS, Prokopov DY, Makunin AI, Komissarov AS, Kudryavtseva AV, Lemskaya NA, Vorobieva NV, Serdyukova NA, Romanenko SA, Gladkikh OL, Graphodatsky AS, Trifonov VA. Genomic organization and physical mapping of tandemly arranged repetitive DNAs in sterlet (Acipenser ruthenus). Cytogenet Genome Res 152: 148-157, 2017

  5. Dymova MA, Zadorozhny AV, Mishukova OV, Khrapov EA, Druzhkova AS, Trifonov VA, Kichigin IG, Tishkin AA, Grushin SP, Filipenko ML. Mitochondrial DNA analysis of ancient sheep from Altai. Anim Genet 48(5): 615-618, 2017

  6. Romanenko SA, Serdyukova NA, Perelman PL, Pavlova SV, Bulatova NS, Golenishchev FN, Stanyon R, Graphodatsky AS. Intrachromosomal rearrangements in rodents from the perspective of comparative region-specific painting. Genes 8(9): 215, 2017

  7. Proskuryakova AA, Kulemzina AI, Perelman PL, Makunin AI, Larkin DM, Farré M, Kukekova AV, Johnson JL, Lemskaya NA, Beklemisheva VR, Roelke-Parker ME, Bellizzi J, Ryder OA, O’Brien SJ, Graphodatsky AS. X chromosome evolution in Cetartiodactyla. Genes 8(9): 216, 2017

  8. Poplavskaya NS, Romanenko SA, Serdyukova NA, Trifonov VA, Yang F, Nie W, Wang J, Bannikova AA, Surov AV, Lebedev VS. Karyotype evolution and phylogenetic relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) inferred from chromosomal painting and molecular data. Cytogenet Genome Res 152: 65-72, 2017

  9. Chiatante G, Capozzi O, Svartman M, Perelman P, Centrone L, Romanenko S, Ishida T, Valeri M, Roelke-Parker ME, Stanyon R. Centromere repositioning explains fundamental number variability in the New World monkey genus SaimiriChromosoma 126(4): 519-529, 2017

  10. Trifonov VA, Makunin AI, Romanenko SA, Biltueva LS, Beklemisheva VR, Pobedintseva MA, Prokopov DYu, Andreyushkova DA, Graphodatsky AS. Whole genome duplications in vertebrate evolution. Mol Cytogenet 10(Suppl 1): 20(L17), 2017

  11. Rajičić M, Romanenko SA, Karamysheva TV, Blagojević J, Adnađević T, Budinski I, Bogdanov AS, Trifonov VA, Rubtsov NB, Vujošević M. The origin of B chromosomes in yellow-necked mice (Apodemus flavicollis) - Break rules but keep playing the game. PLoS ONE  12(3): e0172704, 2017

  12. Dyomin AG, Danilova MI, Mwacharo JM, Masharsky AE, Panteleev AV, Druzhkova AS, Trifonov VA, Galkina SA. Mitochondrial DNA D-loop haplogroup contributions to the genetic diversity of East European domestic chickens from Russia. J Anim Breed Genet 134(2): 98–108, 2017

  13. Druzhkova AS, Makunin AI, Vorobieva NV, Vasiliev SK, Ovodov ND, Shunkov MV, Trifonov VA, Graphodatsky AS. Complete mitochondrial genome of an extinct Equus (Sussemionusovodovi specimen from Denisova cave (Altai, Russia). Mitochondrial DNA Part B 2(1): 79-81, 2017

  14. Romanenko SA. Review on cytogenetic studies in mammals. Chromosome Res 24(Suppl 1): S26-S27, 2016

  15. Proskuryakova AA, Kulemzina AI, Beklemisheva VR, Lemskaya NA, Perelman PL, Graphodatsky AS. Chromosome organization features of the grey whale (Cetacea). Chromosome Res 24(Suppl 1): S28, 2016 

  16. Trifonov  VA, Romanenko SS, Beklemisheva VR, Biltueva LS, Makunin AI, Lemskaya NA, Kulemzina AI, Prokopov DY, Vorobieva NV, Graphodatsky AS. Evolutionary plasticity of Sturgeon genomes. Cytogenet Genome Res 148: 103, 2016

  17. Beklemisheva  V, Perelman P, Lemskaya N, Kulemzina A, Proskuryakova A, Burkanov V, Graphodatsky A. Refinement of the ancestral Carnivore karyotype based on comparative chromosome painting of Pinnipeds (Pinnipedia, Carnivora). Cytogenet Genome Res 148: 105, 2016

  18. Gladkikh OL, Romanenko SA, Lemskaya NA, Serdyukova NA, O’Brien PCM, Kovalskaya JM, Smorkatcheva AV, Golenishchev FN, Perelman PL, Trifonov VA, Ferguson-Smith MA, Yang F, Graphodatsky AS. Rapid karyotype evolution in Lasiopodomys involved at least two autosome – sex chromosome translocations. PLoS ONE 11(12): e0167653, 2016

  19. Trifonov VA, Vorobieva NV, Serdyukova NA, Rens W. FISH with and without COT1 DNA. Fluorescence In Situ Hybridization (FISH). Application Guide. (ed. T Liehr). 2nd ed. 606 p. Springer-Verlag Berlin Heidelberg. 2017. pp. 123-132

  20. Yang F, Graphodatsky AS. Animal probes and ZOO-FISH. Fluorescence In Situ Hybridization (FISH). Application Guide. (ed. T Liehr). 2nd ed. 606 p. Springer-Verlag Berlin Heidelberg. 2017. pp. 395-415

  21. Makunin AI, Kichigin IG, Larkin DM, O’Brien PCM, Ferguson-Smith MA, Yang F, Proskuryakova AA, Vorobieva NV, Chernyaeva EN, O’Brien SJ, Graphodatsky AS, Trifonov VA. Contrasting origin of B chromosomes in two cervids (Siberian roe deer and grey brocket deer) unravelled by chromosomespecific DNA sequencing. BMC Genomics 17: 618, 2016

  22. Kichigin IG, Giovannotti M, Makunin AI, Ng BL, Kabilov MR, Tupikin AE, Barucchi VC, Splendiani A, Ruggeri P, Rens W, O’Brien PCM, Ferguson-Smith MA, Graphodatsky AS, Trifonov VA. Evolutionary dynamics of Anolis sex chromosomes revealed by sequencing of flow sorting-derived microchromosome-specific DNA. Mol Genet Genomics 291: 1955-1966, 2016

  23. Trifonov VA, Romanenko SS, Beklemisheva VR, Biltueva LS, Makunin AI, Lemskaya NA, Kulemzina AI, Stanyon R, Graphodatsky AS. Evolutionary plasticity of acipenseriform genomes. Chromosoma 125: 661-668, 2016

  24. Tchurikov NA, Yudkin DV, Gorbacheva MA, Kulemzina AI, Grischenko IV, Fedoseeva DM, Sosin DV, Kravatsky YuV, Kretova OV. Hot spots of DNA double-strand breaks in human rDNA units are produced in vivo. Sci Reports 6: 25866, 2016

  25. Kulemzina AI, Proskuryakova AA, Beklemisheva VR, Lemskaya NA, Perelman PL, Graphodatsky AS. Comparative chromosome map and heterochromatin features of the gray whale karyotype (Cetacea). Cytogenet Genome Res 148: 25-34, 2016

  26. Beklemisheva VR, Perelman PL, Lemskaya NA, Kulemzina AI, Proskuryakova AA, Burkanov VN, Graphodatsky AS. The ancestral carnivore karyotype as substantiated by comparative chromosome painting of three pinnipeds, the walrus, the steller sea lion and the Baikal seal (Pinnipedia, Carnivora). PLoS ONE 11(1): e0147647, 2016

  27. Romanenko SA, Lemskaya NA, Trifonov VA, Serdyukova NA, O’Brien PCM, Bulatova NSh, Golenishchev FN, Ferguson-Smith MA, Yang F, Graphodatsky AS. Genome-wide comparative chromosome maps of Arvicola amphibius, Dicrostonyx torquatus, and Myodes rutilus. Chromosome Res 24: 145-159, 2016

  28. Dobrynin P,... Makunin A,... Perelman P,... O’Brien SJ. Genomic legacy of the African cheetah, Acinonyx jubatus. Genome Biology 16: 277, 2015

  29. Matveevsky S, Bakloushinskaya I, Tambovtseva V, Romanenko S, Kolomiets O. Analysis of meiotic chromosome structure and behavior in Robertsonian heterozygotes of Ellobius tancrei (Rodentia, Cricetidae): a case of monobrachial homology. Comp Cytogen 9: 691–706, 2015

  30. Romanenko SA, Biltueva LS, Serdyukova NA, Kulemzina AI, Beklemisheva VR, Gladkikh OL, Lemskaya NA, Interesova EA, Korentovich MA, Vorobieva NV, Graphodatsky AS, Trifonov VA. Segmental paleotetraploidy revealed in sterlet (Acipenser ruthenus) genome by chromosome painting. Mol Cytogenet 8: 90, 2015

  31. Korolyuk E, Makunin A, Matveeva T. Relationships and generic delimitation of Eurasian genera of the subtribe Asterinae (Astereae, Asteraceae) using molecular phylogeny of ITS. Turkish J Botany 39: 808-824, 2015

  32. Lemskaya NA, Kartavtseva IV, Rubtsova NV, Golenishchev FN, Sheremetyeva IN, Graphodatsky AS. Chromosome polymorphism in Microtus (Alexandromys) mujanensis (Arvicolinae, Rodentia). (doi: 10.1159/000439096) Cytogenet Genome Res 146: 238-242, 2015 

  33. Romanenko SA, Perelman PP, Trifonov VA, Serdyukova NA, Li T, Fu B, O’Brien PCM, Ng BL, Nie W, Liehr T, Stanyon R, Graphodatsky AS, Yang F. A first generation comparative chromosome map between guinea pig (Cavia porcellus) and humans. PLoS ONE 10(5): e0127937, 2015

  34. Johnson JL, Kosyza A, Kharlamova AV, Gulevich RG, Perelman PL, Fong HTW, Vladimirova AV, Oskina IN, Trut LN, Kukekova AV: Platinum coat color in red fox (Vulpes vulpes) is caused by a mutation in an autosomal copy of KIT. Anim Genet 46: 190–199, 2015

  35. Biltueva L, Kulemzina A, Vorobieva N, Perelman P, Kochneva M, Zhidenova A, Graphodatsky A. A new case of an inherited reciprocal translocation in cattle: rcp(13;26)(q24;q11). Cytogenet Genome Res 144: 208-211, 2014

  36. Avila F, Baily MP, Perelman P, Das PJ, Pontius J, Chowdhary R, Owens E, Johnson WE, Merriwether DA, Raudsepp T. A comprehensive whole-genome integrated cytogenetic map for the alpaca (Lama pacos). Cytogenet Genome Res 144: 193-204, 2014

  37. Jarvis ED,... Perelman P,... Zhang G. Whole-genome analyses resolve early branches in the tree of life of modern birds. Science 346: 1320-1331, 2014

  38. Makunin AI, Dementyeva PV, Graphodatsky AS, Volobujev VT, Kukekova AV, Trifonov VA. Genes on B chromosomes of vertebrates. Mol Cytogenet 7: 99, 2014

  39. Avila F, Das PJ, Kutzler M, Owens E, Perelman P, Rubes J, Hornak M, Johnson WE, Raudsepp T. Development and application of camelid molecular cytogenetic tools. J Hered 105: 858-869, 2014

  40. Kulemzina AI, Perelman PL, Grafodatskaya DA, Nguyen TT, Thompson M, Roelke-Parker ME, Graphodatsky AS. Comparative chromosome painting of pronghorn (Antilocapra americana) and saola (Pseudoryx nghetinhensis) karyotypes with human and dromedary camel probes. BMC Genetics 15: 68, 2014

  41. Thalmann O,... , Druzhkova A, Graphodatsky A,... Wayne RK. Complete mitochondrial genomes of ancient canines suggest a European origin of domestic dogs. Science 342: 871-874, 2013

  42. Kosyakova N, Hamid AB, Chaveerach A, Pinthong K, Siripiyasing P, Supiwong W, Romanenko S, Trifonov V, Fan X. Generation of multicolor banding probes for chromosomes of different species. Mol Cytogen 6: 6, 2013

  43. Bakloushinskaya I, Romanenko SA, Serdukova NA, Graphodatsky AS, Lyapunova EA. A new form of the mole vole Ellobius tancrei Blasius, 1884 (Mammalia, Rodentia) with the lowest chromosome number. Comp Cytogen 7: 163-169, 2013

  44. Cernohorska H, Kubickova S, Kopecna O, Kulemzina AI, Perelman PL, Elder FFB, Graphodatsky A, Rubes J. Molecular cytogenetic insights to the phylogenetic affinities of the giraffe (Giraffa camelopardalis) and pronghorn (Antilocapra americana). Chromosome Res 21: 447-460, 2013

  45. Trifonov VA, Dementyeva PV, Larkin DM, O’Brien PCM, Perelman PL, Yang F, Ferguson-Smith MA, Graphodatsky AS. Transcription of a protein-coding gene on b-chromosomes of the siberian roe deer (Capreolus pygargus). BMC Biology 11: 90, 2013

  46. Romanenko SA, Lebedev VS, Serdukova NA, Feoktistova NY, Surov AV, Graphodatsky AS. Comparative cytogenetics of hamsters of the genus Allocricetulus, Argyropulo 1932 (Cricetidae, Rodentia). Cytogen Genome Res 139: 258-266, 2013

  47. Tchurikov NA, Kretova OV, Fedoseeva DM, Sosin DV, Grachev SA, Serebraykova MV, Romanenko SA, Vorobieva NV, Kravatsky YV. DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomes. PLoS Genet 9(4): e1003429, 2013

  48. Druzhkova AS, Thalmann O, Trifonov VA, Leonard JA, Vorobieva NV, Ovodov ND, Graphodatsky AS, Wayne RK. Ancient DNA analysis affirms the canid from Altai as a primitive dog. PLoS ONE 8(3): e57754, 2013

  49. Dumas F, Houck M, Bigoni F, Perelman P, Romanenko SA, Stanyon R. Chromosome painting of the pygmy tree shrew shows that no derived cytogenetic traits link Primates and Scandentia. Cytogen Genome Res 136: 175-179, 2012

  50. Bakloushinskaya IY, Matveevsky SN, Romanenko SA, Serdukova NA, Kolomiets OL, Spangenberg VE, Lyapunova EA, Graphodatsky AS. A comparative analysis of the mole vole sibling species Ellobius tancrei and E. talpinus (Cricetidae, Rodentia) through chromosome painting and examination of synaptonemal complex structures in hybrids. Cytogen Genome Res 136: 199-207, 2012

  51. Graphodatsky A, Ferguson-Smith MA, Stanyon R. A short introduction to cytogenetics studies in mammals with reference to the present volume. Cytogen Genome Res 137: 83-96, 2012

  52. Perelman PL, Beklemisheva VR, Yudkin DV, Petrina TN, Rozhnov VV, Nie W, Graphodatsky AS. Comparative chromosome painting in Carnivora and Pholidota. Cytogen Genome Res 137: 174-193, 2012

  53. Rubes J, Musilova P, Kopecna O, Kubickova S, Cernohorska H, Kulemsina AI. Comparative molecular cytogenetics in Cetartiodactyla. Cytogen Genome Res 137: 194-207, 2012

  54. Trifonov VA, Musilova P, Kulemsina AI. Chromosome evolution in the Perissodactyla. Cytogen Genome Res 137: 208-217, 2012

  55. Romanenko SA, Volobouev V. Non-sciuromorph rodents karyotypes in evolution. Cytogen Genome Res 137: 233-245, 2012

  56. Romanenko SA, Perelman PL, Trifonov VA, Graphodatsky AS. Chromosomal evolution of Rodentia. Heredity 108: 4-16, 2012

  57. Nie W, Wang J, Su W, Wang D, Tanomtong A, Perelman PL, Graphodatsky AS, Yang F. Chromosomal rearrangements and karyotype evolution in carnivores revealed by chromosome painting. Heredity 108: 17-27, 2012

  58. Wong PBY, Wiley EO, Johnson WE, Ryder OA, O’Brien SJ, Haussler D, Koepfli K-P, Houck ML, Perelman P, Mastromonaco G, Bentley AC, Venkatesh B, Zhang Y, Murphy RW. Genome 10K community of scientists: Tissue sampling and standards for vertebrate genomics. GigaScience 1:8, 2012

  59. Stanyon R, Graphodatsky A. (Ed’s) Evolutionary dynamics of mammalian karyotypes. Karger, Basel, Switzerland, 2012, 208 pp

Selected talks: 
  1. Romanenko S. A review on cytogenetic studies in mammals. 22nd International Colloquium on Animal Cytogenetics and Genomics. July 2-5, 2016, Toulouse, France

  2. Proskuryakova AA. Chromosome organization features of the grey whale (Cetacea). 22nd International Colloquium on Animal Cytogenetics and Genomics. July 2-5, 2016, Toulouse, France

  3. Makunin AI. Discovery of unique regions on B chromosomes in mammals. 3rd B-Chromosome Conference, 7-9 April 2014, Gatersleben, Germany

  4. Romanenko SA. From field sampling to genome projects. 1st symposium "Application and conservation of wildlife cell cultures". 29-30 August 2013. Hamburg, Germany

  5. Romanenko SA. Chromosome evolution in Cricetinae (Myomorpha, Rodentia). 2-6 September 2013, Bologna, Italy

  6. Makunin A. Construction of a SNP-array based high-density genetic linkage map in domestic cat. The 7th International Conference on Advances in Canine and Feline Genomics and Inherited Diseases. 23–27 September 2013, Cambridge, Massachusetts, USA

  7. Graphodatsky AS. The genome diversity and karyotype evolution of mammals. VIth European Congress of Mammology, 19-23 July 2011, Paris, France

  8. Romanenko SA. Chromosome evolution in Rodentia. VIth European Congress of Mammology, 19-23 July 2011, Paris, France

  9. Graphodatsky A. Chromosomal evolution in Rodentia. 6th European Cytogenetic Conference, 7-10 July 2007, Istanbul, Turkey