Department of Diversity and Evolution of Genomes

Laboratory of Animal Cytogenetics

Graphodatsky Alexander
Head of the Department
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Graphodatsky Alexander head DSc (Biology) grafatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Romanenko Svetlana leading research fellow DSc (Biology) rosaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Perelman Polina leading research fellow PhD (Biology) perelmanpatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Beklemisheva Violetta senior research fellow PhD (Biology) beklatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Lemskaya Natalia senior research fellow PhD (Biology) lemnatatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Proskuryakova Anastasia senior research fellow PhD (Biology) andrenaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Kulemzina Anastasia research fellow PhD (Biology) zakalatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Molodtseva Anna junior research fellow PhD (Biology) radaatmcb [dot] nsc [dot] ru
  scopus_logo.jpg Kusliy Maria junior research fellow PhD (Biology) kusliy [dot] mariaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Serdyukova Natalia research fellow   serdatmcb [dot] nsc [dot] ru
      Butakova Yulia engineer   butakovaatmcb [dot] nsc [dot] ru
      Ivanova Ekaterina research assistant    
      Malikov Dmitry part-time research fellow    

Former research workers:

Baturina Anastassiya
Davletshina Guzel
Fofanov Mikhail
Gladkikh Olga
Kichigin Ilya
Makunin Alexey
Prokopov Dmitry
Tishakova Katerina

Research: 
  • Vertebrate chromosomes and genomes
  • Paleogenomics
G10K.jpg

The staff of the Laboratory are among the contributors of a large international consortium for sequencing and genome analysis Genome10K

vgp.jpg

The staff of the Laboratory are among the contributors of a large international consortium for sequencing and analysis of vertebrate genomes

bat1k.jpg

The staff of the Laboratory are among the contributors of a large international consortium for sequencing and analysis of bat genomes

APP_logo.jpg

The staff of the Laboratory are among the contributors of a large international consortium for sequencing and analysis of avian genomes

IMCB_DNA_Zoo.JPG

The staff of the Laboratory are among the contributors of a large international consortium DNA Zoo

Recent publications: 
  1. Proskuryakova AA, Ivanova ES, Perelman PL, Ferguson-Smith MA, Yang F, Okhlopkov IM, Graphodatsky AS. Comparative studies of karyotypes in the Cervidae family. Cytogenet Genome Res, 2022, doi: 10.1159/000527349

  2. Yakupova A, Tomarovsky A, Totikov A, Beklemisheva V, Logacheva M, Perelman PL, Komissarov A, Dobrynin P, Krasheninnikova K, Tamazian G, Serdyukova NA, Rayko M, Bulyonkova T, Cherkasov N, Pylev V, Peterfeld V, Penin A, Balanovska E, Lapidus A, Consortium DZ, O'Brien SJ, Graphodatsky A, Koepfli K-P, Kliver S. Chromosome-length assembly of the Baikal seal (Pusa sibirica) genome reveals a historically large population prior to isolation in lake Baikal. (doi: 10.3390/genes14030619) Genes 14(3): 619, 2023

  3. Beklemisheva VR, Lemskaya NA, Prokopov DY, Perelman PL, Romanenko SA, Proskuryakova AA, Serdyukova NA, Utkin YA, Nie W, Ferguson-Smith MA, Fentang Y, Graphodatsky AS. Maps of constitutive-heterochromatin distribution for four martes species (Mustelidae, Carnivora, Mammalia) show the formative role of macrosatellite repeats in interspecific variation of chromosome structure. (doi: 10.3390/genes14020489) Genes 14(2): 489, 2023

  4. Mesentsev Y, Bondarenko N, Kamyshatskaya O, Nassonova E, Glotova A, Loiko S, Istigechev G, Kulemzina A, Abakumov E, Rayko M, Lapidus A, Smirnov A. Thecochaos is not a myth: study of the genus Thecochaos (Amoebozoa, Discosea) – a rediscovered group of lobose amoeba, with short SSU gene. (doi: 10.1007/s13127-022-00581-9) Org Divers Evol 23: 7-24, 2023

  5. Dumas F, Perelman PL, Biltueva L, Roelke M. Retrotransposon mapping in spider monkey genomes of the family Atelidae (Platyrrhini, Primates) shows a high level of LINE-1 amplification. (doi: 10.4081/jbr.2022.10725J Biol Res 95(2): 10725, 2022

  6. Interesova EA, Babkina IB, Romanov VI, Pozdnyak IV, Davletshina GI, Trifonov VA. New data on small lampreys of the genus Lethenteron (Petromyzontidae) of the Tom river, a typical habitat of the Siberian brook lamprey Lethenteron kessleri. (doi: 10.1134/S003294522206011X) J Ichthyol 62(7): 1230-1236, 2022

  7. Tishakova KV, Prokopov DY, Davletshina GI, Rumyantsev AV, O’Brien PCM, Ferguson-Smith MA, Giovannotti M, Lisachov AP, Trifonov VA. Identification of Iguania ancestral syntenic blocks and putative sex chromosomes in the veiled chameleon (Chamaeleo calyptratus, Chamaeleonidae, Iguania). (doi: 10.3390/ijms232415838Int J Mol Sci 23(24): 15838, 2022

  8. Romanenko SA, Prokopov DY, Proskuryakova AA, Davletshina GI, Tupikin AE, Kasai F, Ferguson-Smith MA, Trifonov VA. The cytogenetic map of the Nile crocodile (Crocodylus niloticus, Crocodylidae, Reptilia) with fluorescence in situ localization of major repetitive DNAs. (doi: 10.3390/ijms232113063Int J Mol Sci 23(21): 13063, 2022

  9. Romanenko S, Trifonov V. Chapter 3. Generation of microdissection-derived painting probes from single copy chromosomes. In: Liehr T (ed.) Cytogenetics and Molecular Cytogenetics, CRC Press, Boca Raton, FL, USA, 2022, pp 27-34 (doi: 10.1201/9781003223658)

  10. Milioto V, Perelman PL, Paglia LL, Biltueva L, Roelke M, Dumas F. Mapping retrotransposon LINE-1 sequences into two Cebidae species and Homo sapiens genomes and a short review on primates. (doi: 10.3390/genes13101742) Genes 13(10): 1742, 2022

  11. Interesova EA, Romanov VI, Davletshina GI, Fedorova VS, Trifonov VA. Dissemination of Misgurnus nikolskyi (Cobitidae) in the south of Western Siberia. (doi: 10.1134/S2075111722030067Russ J Biol Invasions 13(3): 301-304, 2022

  12. de Ferran V, ..., Kliver S, Serdyukova N, ..., Eizirik E. Phylogenomics of the world’s otters. (doi: 10.1016/j.cub.2022.06.036Curr Biol 32(16): 3650-3658.e4, 2022

  13. Molodtseva AS, Makunin AI, Salomashkina VV, Kichigin IG, Vorobieva NV, Vasiliev SK, Shunkov MV, Tishkin AA, Grushin SP, Anijalg P, Tammeleht E, Keis M, Boeskorov GG, Mamaev N, Okhlopkov IM, Kryukov AP, Lyapunova EA, Kholodova MV, Seryodkin IV, Saarma U, Trifonov VA, Graphodatsky AS. Phylogeography of ancient and modern brown bears from eastern Eurasia. (doi: 10.1093/biolinnean/blac009) Biol J Linn Soc 135(4): 722-733, 2022

  14. Suchan T, Kusliy MA, Khan N, Chauvey L, Tonasso-Calvière L, Schiavinato S, Southon J, Keller M, Kitagawa K, Krause J, Bessudnov AN, Bessudnov AA, Graphodatsky AS, Lamas SV, Wilczyński J, Pospuła S, Tunia K, Nowak M, Moskal-delHoyo M, Tishkin AA, Pryor AJ, Outram AK, Orlando L. Performance and automation of ancient DNA capture with RNA hyRAD probes. (doi: 10.1111/1755-0998.13518) Mol Ecol Resour 22(3): 891-907, 2022

  15. Rajičić M, Makunin A, Adnađević T, Trifonov V, Vujošević M, Blagojević J. B chromosomes’ sequences in yellow-necked mice Apodemus flavicollis — exploring the transcription. (doi: 10.3390/life12010050Life 12(1): 50, 2022

  16. Ceraulo S, Perelman PL, Dumas F. Massive LINE-1 retrotransposon enrichment in tamarins of the Cebidae family (Platyrrhini, Primates) and its significance for genome evolution. (doi: 10.1111/jzs.12536J Zool Syst Evol Res 59(8): 2553-2561, 2021

  17. Beklemisheva VR, Belokopytova PS, Fishman VS, Menzorov AG. Derivation of ringed seal (Phoca hispida) induced multipotent stem cells. (doi: 10.1089/cell.2021.0037Cell Reprogram 23(6): 326-335, 2021

  18. Gridina MM, Shitik EM, Lemskaya NA, Minina JM, Grishchenko IV, Dolskiy AA, Shorina AR, Maksimova YV, Yudkin DV. Derivation of iPS cell line (ICGi032-A) from a patient affected with fragile X syndrome. (doi: 10.1016/j.scr.2021.102615Stem Cell Res 57: 102615, 2021

  19. Nikitin SV, Knyazev SP, Trifonov VA, Proskuryakova AA, Shmidt YuD, Shatokhin KS, Zaporozhets VI, Bashur DS, Korshunova EV, Ermolaev VI. Unusual congenital polydactyly in mini-pigs from the breeding group of the Institute of Cytology and Genetics (Novosibirsk, Russia). (doi: 10.18699/VJ21.074) Vavilov J Genet Breed 25(6): 652-660, 2021

  20. Tamazian G, Dobrynin P, Zhuk A, Zhernakova DV, Perelman PL, Serdyukova NA, Graphodatsky AS, Komissarov A, Kliver S, Cherkasov N, Scott AF, Mohr DW, Koepfli K-P, O’Brien SJ, Krasheninnikova K. Draft de novo genome assembly of the elusive jaguarundi, Puma yagouaroundi. (doi: 10.1093/jhered/esab036) J Heredity 112(6): 540-548, 2021

  21. Librado P, ... Kusliy MA, ... Graphodatsky AS, ... Orlando L. The origins and spread of domestic horses from the Western Eurasian steppes. (doi: 10.1038/s41586-021-04018-9) Nature 598: 634-640, 2021

  22. Lemskaya NA, Romanenko SA, Rezakova MA, Filimonova EA, Prokopov DY, Dolskiy AA, Perelman PL, Maksimova YV, Shorina AR, Yudkin DV. A rare familial rearrangement of chromosomes 9 and 15 associated with intellectual disability: a clinical and molecular study. (doi: 10.1186/s13039-021-00565-yMol Cytogenet 14: 47, 2021

  23. Ceraulo S, Perelman PL, Mazzoleni S, Rovatsos M, Dumas F. Repetitive sequence distribution on SaguinusLeontocebus and Leontopithecus tamarins (Platyrrhine, Primates) by mapping telomeric (TTAGGG) motifs and rDNA loci. (doi: 10.3390/biology10090844Biology 10(9): 844, 2021

  24. Totikov A, Tomarovsky A, Prokopov D, Yakupova A, Bulyonkova T, Derezanin L, Rasskazov D, Wolfsberger WW, Koepfli K-P, Oleksyk TK, Kliver S. Chromosome-level genome assemblies expand capabilities of genomics for conservation biology. (doi: 10.3390/genes12091336Genes 12(9): 1336, 2021

  25. Romanenko SA, Smorkatcheva AV, Kovalskaya YM, Prokopov DY, Lemskaya NA, Gladkikh OL, Polikarpov IA, Serdyukova NA, Trifonov VA, Molodtseva AS, O’Brien PCM, Golenishchev FN, Ferguson-Smith MA, Graphodatsky AS. Complex structure of Lasiopodomys mandarinus vinogradovi sex chromosomes, sex determination, and intraspecific autosomal polymorphism. In: Ruiz-Herrera A, Farré-Belmonte M (eds) Mechanisms Driving Karyotype Evolution and Genomic Architecture, MDPI, Switzerland, 2021, pp 193-209 (doi: 10.3390/books978-3-0365-0157-4)

  26. Proskuryakova AA, Kulemzina AI, Perelman PL, Yudkin DV, Lemskaya NA, Okhlopkov IM, Kirillin EV, Farré M, Larkin DM, Roelke-Parker ME, O’Brien SJ, Bush M, Graphodatsky AS. Comparative chromosome mapping of musk ox and the X chromosome among some bovidae species. In: Ruiz-Herrera A, Farré-Belmonte M (eds) Mechanisms Driving Karyotype Evolution and Genomic Architecture, MDPI, Switzerland, 2021, pp 211-224 (doi: 10.3390/books978-3-0365-0157-4)

  27. Buggiotti L, Yurchenko AA, Yudin NS, Vander Jagt CJ, Vorobieva NV, Kusliy MA, Vasiliev SK, Rodionov AN, Boronetskaya OI, Zinovieva NA, Graphodatsky AS, Daetwyler HD, Larkin DM. Demographic history, adaptation, and NRAP convergent evolution at amino acid residue 100 in the world northernmost cattle from Siberia. (doi: 10.1093/molbev/msab078) Mol Biol Evol 38(8): 3093-3110, 2021

  28. Lisachov AP, Tishakova KV, Romanenko SA, Molodtseva AS, Prokopov DYu, Pereira JC, Ferguson-Smith MA, Borodin PM, Trifonov VA. Whole-chromosome fusions in the karyotype evolution of Sceloporus (Iguania, Reptilia) are more frequent in sex chromosomes than autosomes. (doi: 10.1098/rstb.2020.0099Philos Trans R Soc Lond B Biol Sci 376(1833): 20200099, 2021

  29. Kuhl H, ... Prokopov D, ... Stöck M. A 180 Myr-old female-specific genome region in sturgeon reveals the oldest known vertebrate sex determining system with undifferentiated sex chromosomes. (doi: 10.1098/rstb.2020.0089Philos Trans R Soc Lond B Biol Sci 376(1832): 20200089, 2021

  30. Karamysheva T, Romanenko S, Makunin A, Rajičić M, Bogdanov A, Trifonov V, Blagojević J, Vujošević M, Orishchenko K, Rubtsov N. New data on organization and spatial localization of B-chromosomes in cell nuclei of the yellow-necked mouse Apodemus flavicollis. (doi: 10.3390/cells10071819Cells 10(7): 1819, 2021

  31. Romanenko SA, Malikov VG, Mahmoudi A, Golenishchev FN, Lemskaya NA, Pereira JC, Trifonov VA, Serdyukova NA, Ferguson-Smith MA, Aliabadian M, Graphodatsky AS. New data on comparative cytogenetics of the mouse-like hamsters (Calomyscus Thomas, 1905) from Iran and Turkmenistan. (doi: 10.3390/genes12070964Genes 12(7): 964, 2021

  32. Höhne C, Prokopov D, Kuhl H, Du K, Klopp C, Wuertz S, Trifonov V, Stöck M. The immune system of sturgeons and paddlefish (Acipenseriformes): a review with new data from a chromosome‐scale sturgeon genome. (doi: org/10.1111/raq.12542) Rev Aquacult 13(3): 1709-1729, 2021

  33. Pobedintseva MA, Reshetnikova SN, Serdyukova NA, Bishani A, Trifonov VA, Interesova EA. Genetic diversity of the prussian carp Carassius gibelio (Cyprinidae) in the middle Ob basin. (doi: 10.1134/S1022795421040116) Russ J Genet 57(4): 446-452, 2021

  34. Lisachov A, Andreyushkova D, Davletshina G, Prokopov D, Romanenko S, Galkina S, Saifitdinova A, Simonov E, Borodin P, Trifonov V. Amplified fragments of an autosome-borne gene constitute a significant component of the W sex chromosome of Eremias velox (Reptilia, Lacertidae). (doi: 10.3390/genes12050779Genes 12(5): 779, 2021

  35. Romanenko SA, Lebedev VS, Bannikova AA, Pavlova SV, Serdyukova NA, Feoktistova NYu, Jiapeng Q, Yuehua S, Surov AV, Graphodatsky AS. Karyotypic and molecular evidence supports the endemic Tibetan hamsters as a separate divergent lineage of Cricetinae. (doi: 10.1038/s41598-021-89890-1Sci Rep 11: 10557, 2021

  36. Bishani A, Prokopov DYu, Romanenko SA, Molodtseva AS, Perelman PL, Interesova EA, Beklemisheva VR, Graphodatsky AS, Trifonov VA. Evolution of tandemly arranged repetitive DNAs in three species of Cyprinoidei with different ploidy levels. (doi: 10.1159/000513274Cytogenet Genome Res 161: 32-42, 2021

  37. Mordvinov VA, Minkova GA, Kovner AV, Ponomarev DV, Lvova MN, Zaparina O, Romanenko SA, Shilov AG, Pakharukova MY. A tumorigenic cell line derived from a hamster cholangiocarcinoma associated with Opisthorchis felineus liver fluke infection. (doi: 10.1016/j.lfs.2021.119494) Life Sci 277: 119494, 2021

  38. Lemskaya NA, Romanenko SA, Maksimova YV, Shorina AR, Yudkin DV. Identification of satellited markers by microdissection and fluorescence in situ hybridization: a clinical case of isodicentric chromosome 22. (doi: 10.1186/s43042-021-00146-zEgypt J Med Hum Genet 22: 24, 2021

  39. Kusliy MA, Vorobieva NV, Tishkin AA, Makunin AI, Druzhkova AS, Trifonov VA, Iderkhangai T-O, Graphodatsky AS. Traces of late Bronze and early Iron Age Mongolian horse mitochondrial lineages in modern populations. (doi: 10.3390/genes12030412Genes 12(3): 412, 2021

  40. Evdokimov A., Popov A., Ryabchikova E., Koval O., Romanenko S., Trifonov V., Petruseva I., Lavrik I., Lavrik O. Uncovering molecular mechanisms of regulated cell death in the naked mole rat. (doi: 10.18632/aging.202577) Aging (Albany NY) 13(3): 3239-3253, 2021

  41. Iannucci A, Makunin AI, Lisachov AP, Ciofi C, Stanyon R, Svartman M, Trifonov VA. Bridging the gap between vertebrate cytogenetics and genomics with single-chromosome sequencing (ChromSeq). (doi: 10.3390/genes12010124) Genes 12(1): 124, 2021

  42. Dolskiy AA, Yarushkin AA, Grishchenko IV, Lemskaya NA, Pindyurin AV, Boldyreva LV, Pustylnyak VO, Yudkin DV. miRNA expression and interaction with the 3′UTR of FMR1 in FRAXopathy pathogenesis. (doi: 10.1016/j.ncrna.2020.11.006) Non-coding RNA Res 6(1): 1-7, 2021

Publications for previous years

Selected talks: 
  1. Grafodatsky AS. From 2n to VGP. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  2. Druzhkova AS. The phylogeographical history of the brown bear (Ursus arctos Linnaeus) in Northeast Eurasia. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  3. Proskuryakova AA. Evolution of X chromosome in the order Cetartiodactyla. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  4. Makunin AI. Summary of mammalian B chromosome sequencing. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  5. Romanenko SA. Intrachromosomal rearrangements within evolutionarily conserved syntenic blocks. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  6. Beklemisheva V. Pinniped karyotype evolution substantiated by comparative chromosome painting of 10 pinniped species (Pinnipedia, Carnivora). 23rd International Colloquium on Animal Cytogenetics and Genomics, June 9-12, 2018, Saint-Petersburg, Russia

  7. Proskuryakova A. X chromosome evolution in Cetartiodactyla. 23rd International Colloquium on Animal Cytogenetics and Genomics, June 9-12, 2018, Saint-Petersburg, Russia

  8. Beklemisheva V. Refinement of the ancestral carnivore karyotype based on the comparative chromosome painting of pinnipeds (Pinnipedia, Carnivora). 21st International Chromosome Conference. July 10-13, 2016, Foz do Iguaçu, Brazil

  9. Romanenko S. A review on cytogenetic studies in mammals. 22nd International Colloquium on Animal Cytogenetics and Genomics. July 2-5, 2016, Toulouse, France

  10. Proskuryakova AA. Chromosome organization features of the grey whale (Cetacea). 22nd International Colloquium on Animal Cytogenetics and Genomics. July 2-5, 2016, Toulouse, France

  11. Makunin AI. Discovery of unique regions on B chromosomes in mammals. 3rd B-Chromosome Conference, 7-9 April 2014, Gatersleben, Germany

  12. Romanenko SA. From field sampling to genome projects. 1st symposium "Application and conservation of wildlife cell cultures". 29-30 August 2013. Hamburg, Germany

  13. Romanenko SA. Chromosome evolution in Cricetinae (Myomorpha, Rodentia). 2-6 September 2013, Bologna, Italy

  14. Makunin A. Construction of a SNP-array based high-density genetic linkage map in domestic cat. The 7th International Conference on Advances in Canine and Feline Genomics and Inherited Diseases. 23–27 September 2013, Cambridge, Massachusetts, USA

  15. Graphodatsky AS. The genome diversity and karyotype evolution of mammals. VIth European Congress of Mammology, 19-23 July 2011, Paris, France

  16. Romanenko SA. Chromosome evolution in Rodentia. VIth European Congress of Mammology, 19-23 July 2011, Paris, France

  17. Graphodatsky A. Chromosomal evolution in Rodentia. 6th European Cytogenetic Conference, 7-10 July 2007, Istanbul, Turkey

Collaboration: 
  • Cambridge Resource Centre for Comparative Genomics, University of Cambridge, UK

  • National Cancer Institute at Frederick, MD, USA

  • Cornell University, Ithaca, NY, USA

  • University of North Carolina at Chapel Hill, NC, USA

  • Institut für Humangenetik, Jena, Germany

  • Muséum national d'histoire naturelle, Paris, France

  • Université Fédérale Toulouse Midi-Pyrénées, Toulouse, France

  • Università degli Studi di Firenze, Florence, Italy

  • Kunming Institute of Zoology, China

  • Universidade de São Paulo, Câmpus de Rio Claro, Brasil

  • University of Illinois at Urbana, Champaign, IL, USA

  • Università degli Studi di Palermo, Italy