Laboratory of Human Disease Models

Staff:

Kozhevnikova Elena	head	PhD (Biology)	kozhevnikovamcb [dot] nsc [dot] ru
Popova Julia	part-time junior research fellow	PhD (Biology)	popovamcb [dot] nsc [dot] ru
Medvedeva Sajdakova) Snezhanna	junior research fellow		medvedevamcb [dot] nsc [dot] ru
Andrejeva Jelizaveta	research assistant		andreeva [dot] emcb [dot] nsc [dot] ru
Nikelvart Ekaterina	research assistant		nikelvartmcb [dot] nsc [dot] ru
Chanushkina Kseniya	research assistant		chanushkinamcb [dot] nsc [dot] ru
Achasova Kseniya	part-time senior research fellow	PhD (Biology)	achasovamcb [dot] nsc [dot] ru
Morozova Maryana	part-time junior research fellow	PhD (Biology)	morozovamcb [dot] nsc [dot] ru
Saeidi Arsalan	part-time junior research fellow		saeidimcb [dot] nsc [dot] ru

Research:

The Laboratory of Human Disease Models focuses on studying the molecular and genetic mechanisms of inflammatory bowel diseases (IBD) and associated disorders. We utilize laboratory animals and 3D colonic organoids to recapitulate IBD in the lab. By combining these models with confocal microscopy, “-omic” approaches, and functional tests, we investigate the molecular mechanisms of epithelial barrier disruption in IBD. Additionally, the laboratory explores the role of the gut microbiota and its metabolism as regulators of psychiatric disorders associated with IBD, such as depression and anxiety.

Recent publications:

Razuvaeva AV, Graziadio L, Palumbo V, Pavlova GA, Popova JV, Pindyurin AV, Bonaccorsi S, Somma MP, Gatti M. The multiple mitotic roles of the ASPM orthologous proteins: Insight into the etiology of ASPM-dependent microcephaly. (doi: 10.3390/cells12060922) Cells 12(6): 922, 2023
Morozova MV, Borisova MA, Snytnikova OA, Achasova KM, Litvinova EA, Tsentalovich YuP, Kozhevnikova EN. Colitis-associated intestinal microbiota regulates brain glycine and host behavior in mice. (doi: 10.1038/s41598-022-19219-z) Sci Rep 12: 16345, 2022
Popova JV, Pavlova GA, Razuvaeva AV, Yarinich LA, Andreyeva EN, Anders AF, Galimova YA, Renda F, Somma MP, Pindyurin AV, Gatti M. Genetic control of kinetochore-driven microtubule growth in Drosophila mitosis. (doi: 10.3390/cells11142127) Cells 11(14): 2127, 2022
Bets VD, Achasova KM, Borisova MA, Kozhevnikova EN, Litvinova EA. Role of Mucin 2 glycoprotein and L-fucose in interaction of immunity and microbiome within the experimental model of inflammatory bowel disease. (doi: 10.1134/S0006297922040010) Biochemistry (Moscow) 87(4): 301-318, 2022
Omelina ES, Yushkova AA, Motorina DM, Volegov GA, Kozhevnikova EN, Pindyurin AV. Optogenetic and chemical induction systems for regulation of transgene expression in plants: use in basic and applied research. (doi: 10.3390/ijms23031737) Int J Mol Sci 23(3): 1737, 2022
Boldyreva LV, Morozova MV, Saydakova SS, Kozhevnikova EN. Fat of the gut: epithelial phospholipids in inflammatory bowel diseases. (doi: 10.3390/ijms222111682) Int J Mol Sci 22(21): 11682, 2021
Achasova KM, Kozhevnikova EN, Borisova MA, Litvinova EA. Fucose ameliorates Tritrichomonas sp.-associated illness in tntibiotic-treated Muc2^−/− mice. (doi: 10.3390/ijms221910699) Int J Mol Sci 22(19): 10699, 2021
Litvinova EA, Bets VD, Feofanova NA, Gvozdeva OV, Achasova KM, Alperina EL, Kozhevnikova EN. Dietary fucose affects macrophage polarization and reproductive performance in mice. (doi: 10.3390/nu13030855) Nutrients 13(3): 855, 2021
Boldyreva LV, Yarinich LA, Kozhevnikova EN, Ivankin AV, Lebedev MO, Pindyurin AV. Fine gene expression regulation by minor sequence variations downstream of the polyadenylation signal. (doi: 10.1007/s11033-021-06160-z) Mol Biol Rep 48: 1539-1547, 2021

Research Groups