Laboratory of Immunogenetics

Taranin Alexander
Head of the Laboratory

Staff: 
      Name Position Academic
degree
Contacts
thomson_logo.gif scopus_logo.jpg Taranin Alexander head DSc (Biology) taraninatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Volkova Olga senior research fellow PhD (Biology) volkovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Mechetina Lyudmila senior research fellow PhD (Biology) lucieatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Najakshin Alexander senior research fellow PhD (Biology) najakshinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Chikaev Nikolay senior research fellow PhD (Biology) na_chikatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Guselnikov Sergey senior research fellow PhD (Biology) sguselnikovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Gorchakov Andrey senior research fellow PhD (Biology) gorchakovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Kulemzin Sergey senior research fellow PhD (Biology) skulemzinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Baranov Konstantin senior research fellow PhD (Biology) baranovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Chikaev Anton research fellow PhD (Biology) chikaevatmcb [dot] nsc [dot] ru
      Sizentsova Yana research assistant   sizentsova [dot] yanaatmcb [dot] nsc [dot] ru
      Belovezhets Tatiana research assistant   belovezhecatmcb [dot] nsc [dot] ru
      Matvienko Daria research assistant    
      Mayerova Anna engineer   maerovaatmcb [dot] nsc [dot] ru
      Starikovskaya Antonina lab technician   astarikovskaatmcb [dot] nsc [dot] ru
      Chernishova Zoya lab technician   z_chernishovaatmcb [dot] nsc [dot] ru

Former research workers:

Chernikova Daria
Kuznetsova Valeria
Reshetnikova Evdokia
Sokratyan Arpine

Research: 
EuroMabNet.png

The staff of the Laboratory are participants of EuroMAbNet - the European network of laboratories working in the field of monoclonal antibodies

Recent publications: 
  1. Matvienko DA, Kulemzin  SV, Smagina AS, Belovezhets TN, Chikaev AN, Volkova OY, Chikaev NA, Koval OA, Kuligina EV, Taranin AV, Gorchakov AA. Analysis of in vitro activity of PSCA-specific CARs in the context of human NK cell line YT. (doi: 10.18620/ctt-1866-8836-2018-7-2-70-77Cell Therapy Transplantation (CTT) 7(2): 70-77, 2018

  2. Reshetnikova E, Guselnikov S, Volkova O, Baranov K, Taranin A, Mechetina L. B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans. (doi: 10.1002/cyto.b.21611Cytometry B Clin Cytom 94(4): 549-704, 2018

  3. Gorchakov AA, Sizentsova YaG, Belovezhets TN, Kulemzin SV, Chikaev AN, Guselnikov SV, Taranin AV. Design and functional analysis of Fn3-based bi-specific cars. (doi: 10.1016/j.ymthe.2018.05.001Mol Therapy 26 (5 S1): 60, 2018

  4. Gorchakov A, Chikaev AN, Kulemzin SV, Volkova OY, Chernikova DS, Matvienko DA, Belovezhets TN, Sokratyan AM, Kuznetsova VV, Taranin AV. ECAR-NK cell platform: enhancing the CAR-mediated NK cell cytotoxicity via blockade of the CD47/SIRPa axis. (doi: 10.1016/j.ymthe.2018.05.001Mol Therapy 26 (5 S1): 199, 2018

  5. Guselnikov SV, Baranov KO, Najakshin AM, Mechetina LV, Chikaev NA, Makunin AI, Kulemzin SV, Andreyushkova DA, Stöck M, Wuertz S, Gessner J, Warren WC, Schartl M,  Trifonov VA, Taranin AV. Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes. (doi: 10.3389/fimmu.2018.01079Front Immunol 9: 1079, 2018

  6. Sato E, Zaboronok A, Yamamoto T, Nakai K, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Isobe T, Mathis BJ, Matsumura A. Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. (doi: 10.1093/jrr/rrx071J Radiat Res 59(2): 101-107, 2018

  7. Kulemzin SV, Gorchakov AA, Chikaev AN, Kuznetsova VV, Volkova OY, Matvienko DA, Petukhov AV, Zaritskey AY, Taranin AV. VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cells. (doi: 10.18632/oncotarget.24078) Oncotarget 9(10): 9021-9029, 2018

  8. Koval O, Volkova O, Kulemzin S, Gorchakov A, Tkachenko A, Nushtaeva A, Kuligina E, Richter V, Taranin A. NK-cell based delivery of anticancer therapeutics. (doi: 10.1093/annonc/mdx711.050) Annals Oncology 28(Suppl 11): 69P, 2017

  9. Gorchakov A, Kulemzin S, Kuznetsova V, Volkova O, Taranin A. FnCARs: a platform expanding the repertoire of proteins targetable with chimeric antigen receptors. Mol Therapy 25(5S1): 272, 2017

  10. Zaboronok AA, Byvaltsev VA, Kanygin VV, Iarullina AI, Kichigin AI, Taranin AV, Volkova OYu, Mechetina LV, Taskaev SYu, Muhamadiyarov RA, Zavyalov EL, Nakai K, Sato E, Yamamoto T, Mathis BJ, Matsumura A. Boron-neutron capture therapy in Russia: preclinical evaluation of efficacy and perspectives of its application in neuro-oncology. New Armenian Med J 11(1): 6-15, 2017

  11. Sherin PS, López-Duarte I, Dent MR, Kubánková M, Vyšniauskas A, Bull JA, Reshetnikova ES, Klymchenko AS, Tsentalovich YP, Kuimova MK. Visualising the membrane viscosity of porcine eye lens cells using molecular rotors. (doi: 10.1039/C6SC05369FChem Sci 8: 3523-3528, 2017

  12. Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov AA. CAR T-cell therapy: Balance of efficacy and safety. Mol Biology 51(2): 237-250, 2017

  13. Kulemzin SV, Chikaev NA, Volkova OY, Kuznetsova VV, Taranin AV, Gorchakov AA. Modular lentiviral vector system for chimeric antigen receptor design optimization. Rus J Bioorg Chem 43(2): 107-114, 2017

  14. Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov АA. Engineering chimeric antigen receptors. Acta Naturae 9(1): 6-14, 2017

  15. Sokratian A, Baranov K, Guselnikov S, Chikaev N, Volkova O, Mechetina L, Taranin A, Gorchakov A , Kulemzin S. Identification of the human SLAMF9-receptor complex. Tissue Antigens 85: 381-382, 2015

  16. Guselnikov SV, Grayfer L, De Jesús Andino F, Rogozin IB, Robert J, Taranin AV. Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis. (doi: 10.1016/j.dci.2015.07.002Dev Comp Immunol 53: 158-168, 2015

  17. Romanets-Korbut O, Najakshin AM, Yurchenko M, Malysheva TA, Kovalevska L, Shlapatska LM, Zozulya YA, Taranin AV, Horvat B, Sidorenko SP. Expression of CD150 in tumors of the central nervous system: identification of a novel isoform. (doi: 10.1371/journal.pone.0118302PLoS One 10(2): e0118302, 2015

  18. Reguzova AY, Karpenko LI, Mechetina LV, Belyakov IM. Peptide–MHC multimer-based monitoring of CD8 T-cells in HIV-1 infection and AIDS 5 vaccine development. (doi: 10.1586/14760584.2015.962520Expert Rev Vaccines 14: 69-84, 2015

  19. Volkova O, Guselnikov S, Mechetina L, Chikaev N, Baranov K, Kulemzin S, Reshetnikova E, Najakshin A, Taranin A. Development and characterization of domain-specific monoclonal antibodies produced against human SLAMF9. (doi: 10.1089/mab.2014.0010Monoclon Antib Immunodiagn Immunother 33: 209-214, 2014

  20. Alekseyenko AA, Gorchakov AA, Zee BM, Fuchs SM, Kharchenko PV, Kuroda MI. Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. (doi: 10.1101/gad.241950.114Genes Dev 28: 1445-1460, 2014

  21. Alekseyenko AA, Gorchakov AA, Kharchenko PV, Kuroda MI. Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification. (doi: 10.1073/pnas.1400648111Proc Natl Acad Sci USA 111: 2488-2493, 2014

  22. Kulemzin S, Chikaev N, Volkova O, Reshetnikova E, Taranin A, Najakshin A, Mechetina L. Characterization of human FCRLA isoforms. (doi: 10.1016/j.imlet.2013.05.011Immunol Lett 152: 153-158, 2013

  23. Pomaznoy M, Tatkov S, Katokhin A, Afonnikov D, Babenko V, Furman D, Brusentsov I, Belavin P, Najakshin A, Guselnikov S, Vasiliev G, Sivkov A, Prokhortchouk E, Skryabin K, Mordvinov V. Adult Opisthorchis felineus major protein fractions deduced from transcripts: Comparison with liver flukes Opisthorchis viverrini and Clonorchis sinensis. (doi: 10.1016/j.exppara.2013.07.011Exp Parasitol 135: 297-306, 2013

  24. Zhou Q, Ellison CE, Kaiser VB, Alekseyenko AA, Gorchakov AA, Bachtrog D. The epigenome of evolving Drosophila neo-sex chromosomes: Dosage compensation and heterochromatin formation. (doi: 10.1371/journal.pbio.1001711PLoS Biol 11 (11): e1001711, 2013

  25. Alekseyenko AA, Ellison CE, Gorchakov AA, Zhou Q, Kaiser VB, Toda N, Walton Z, Peng S, Park PJ, Bachtrog D, Kuroda MI. Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila. (doi: 10.1101/gad.215426.113Genes Dev 27: 853-858, 2013

  26. Wang CI, Alekseyenko AA, LeRoy G, Elia AEH, Gorchakov AA, Britton LMP, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. (doi: 10.1038/nsmb.2477Nat Struct Mol Biol 20: 202-209, 2013

Selected talks: 
  1. Gorchakov A. Adnectin-based CARs: pros and cons. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  2. Chikaev A. CD47/SIRPa blockers and CARs: together we stand. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  3. Belovezhets T. Quest for the optimal NK-cell line as a CAR carrier. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  4. Kulemzin S. Forging the Natural Killer with genome editing. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  5. Kulemzin SV. Generation of NK-cell lines with enhanced therapeutic potential. International congress “CRISPR-2018”, September 10-14, 2018, Novosibirsk, Russia

  6. Matvienko D. PSMA- and PSCA-specific chimeric antigen receptors (CARs) for prostate cancer therapy. The 25th International Students Congress of bio(Medical) Science (ISCOMS 2018) 4-8 June 2018, Groningen, Netherlands

  7. Gorchakov A. Optimal CAR design and development of an ECAR NK cell platform. XI Raisa Gorbacheva Memorial Meeting “Hematopoetic Stem Cell Transplantation. Gene and Cellular Therapy”, Workshop on Genome Editing in Hematology & HSCT, 14-16 September 2017, St. Petersburg, Russia

  8. Mechetina L. Artificial antibodies based on human 10Fn3 scaffold. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  9. Baranov K. Multimeric 10Fn3-based proteins as inductors of anti-idiotypic antibodies. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  10. Mechetina LV. New intacellular B cell marker FCRLA. 5th EuroMabNet meeting, 23-24 September 2013, Menorca, Spain

  11. Mechetina L. FCRL6 receptor: expression and associated proteins. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  12. Baranov KO. Searching for ligands of the FcR-like B cell-specific receptors. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  13. Taranin A. Molecular Evolution of the FcR- and KIR-like Receptors in Tetrapods. ISDCI 10th International Congress,
    1-6 July 2006, Charleston, USA

  14. Guselnikov S. Evolution of FcR- and KIR-like leukocyte receptors: from Teleostei to Mammalia. Eastern Great Lakes Molecular Evolution Meeting. Koffler Institute for Pharmacy Management, University of Toronto, 30 April 2005, Toronto, Canada

Collaboration: 
  • University of Alabama at Birmingham, AL, USA

  • University of Rochester Medical Center, NY, USA

  • Universitat de Barcelona, Spain

  • Faculty of Medicine, University of Tsukuba, Japan