Одной из наиболее актуальных и динамически развивающихся областей биологии в последние годы стало направление сравнительного изучения геномов и хромосом. Это направление может получить дальнейшее развитие за счет создания в НГУ Лаборатории структурной, функциональной и сравнительной геномики на базе сотрудничества с лабораториями ИМКБ СО РАН. В Лаборатории будут проведены работы по следующим направлениям:

• структурно-функциональная организация хромосом
• кластерная организация генов
• молекулярная организация гетерохроматина животных и растений
• разработка системы для внесения направленных модификаций в геном
• организация и эволюция хромосом и геномов позвоночных
• палеогеномика
• структура добавочных хромосом
• хромосомные системы определения пола
• функциональный и эволюционный анализ геномной компоненты иммунной системы

В рамках проекта были выпущены следующие статьи:

2018

1. Strunov A, Boldyreva LV, Andreyeva EN, Pavlova GA, Popova JV, Razuvaeva AV, Anders AF, Renda F, Pindyurin AV, Gatti M, Kiseleva E. Ultrastructural analysis of mitotic Drosophila S2 cells identifies distinctive microtubule and intracellular membrane behaviors. (doi: 10.1186/s12915-018-0528-1) BMC Biol 16: 68, 2018
   (IF = 6.779)

2. Guselnikov SV, Baranov KO, Najakshin AM, Mechetina LV, Chikaev NA, Makunin AI, Kulemzin SV, Andreyushkova DA, Stöck M, Wuertz S, Gessner J, Warren WC, Schartl M, Trifonov VA, Taranin AV. Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes. Front Immunol 9: 1079, 2018
   (IF = 6.429)

3. Laktionov PP, Maksimov DA, Romanov SE, Antoshina PA, Posukh OV, White‑Cooper H, Koryakov DE, Belyakin SN. Genome‑wide analysis of gene regulation mechanisms during Drosophila spermatogenesis. Epigenetics Chromatin 11: 14, 2018
   (IF = 5.189)

4. Kulemzin SV, Gorchakov AA, Chikaev AN, Kuznetsova VV, Volkova OY, Matvienko DA, Petukhov AV, Zaritskey AY, Taranin AV. VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cells. Oncotarget 9(10): 9021-9029, 2018
   (IF = 5.168)

5. Makunin AI, Rajičić M, Karamysheva TV, Romanenko SA, Druzhkova AS, Blagojević J, Vujošević M, Rubtsov NB, Graphodatsky AS, Trifonov VA. Low-pass single-chromosome sequencing of human small supernumerary marker chromosomes (sSMCs) and Apodemus B chromosomes. Chromosoma, 2018, doi: 10.1007/s00412-018-0662-0
   (IF = 4.414)

6. Perelman PL, Pichler R, Gaggl A, Larkin DM, Raudsepp T, Alshanbari F, Holl HM, Brooks SA, Burger PA, Periasamy K. Construction of two whole genome radiation hybrid panels for dromedary (Camelus dromedarius): 5000_RAD and 15000_RAD. (doi: 10.1038/s41598-018-20223-5) Sci Reports 8: 1982, 2018
   (IF = 4.259)

7. Capozzi O, Stanyon R, Archidiacono N, Ishida T, Romanenko SA, Rocchi M. Rapid emergence of independent “chromosomal lineages” in silvered-leaf monkey triggered by Y/autosome translocation. (doi: 10.1038/s41598-018-21509-4) Sci Reports 8: 3250, 2018
   (IF = 4.259)

8. Proskuryakova AA, Kulemzina AI, Perelman PL, Serdukova NA, Ryder OA, Graphodatsky AS. The case of X and Y localization of nucleolus organizer regions (NORs) in Tragulus javanicus (Cetartiodactyla, Mammalia). (doi: 10.3390/genes9060312) Genes 9(6): 312, 2018
   (IF = 3.600)

9. Bikchurina TI, Tishakova KV, Kizilova EA, Romanenko SA, Serdyukova NA, Torgasheva AA, Borodin PM. Chromosome synapsis and recombination in male-sterile and female-fertile interspecies hybrids of the dwarf hamsters (Phodopus, Cricetidae). (doi:10.3390/genes9050227) Genes 9: 227, 2018
   (IF = 3.600)

10. Pokholkova GV, Demakov SA, Andreenkov OV, Andreenkova NG, Volkova EI, Belyaeva ES, Zhimulev IF. Tethering of CHROMATOR and dCTCF proteins results in decompaction of condensed bands in the Drosophila melanogaster polytene chromosomes but does not affect their transcription and replication timing. (doi: 10.1371/journal.pone.0192634) PLoS ONE 13(4): e0192634, 2018
    (IF = 2.806)

11. Kolesnikova TD, Goncharov FP, Zhimulev IF. Similarity in replication timing between polytene and diploid cells is associated with the organization of the Drosophila genome. (doi: 10.1371/journal.pone.0195207) PLoS ONE 13(4): e0195207, 2018
    (IF = 2.806)

12. Sato E, Zaboronok A, Yamamoto T, Nakai K, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Isobe T, Mathis BJ, Matsumura A. Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. J Radiat Res 59(2): 101-107, 2018
    (IF = 1.788)

13. Pobedintseva MA, Makunin AI, Kichigin IG, Kulemzina AI, Serdyukova NA, Romanenko SA, Vorobieva NV, Interesova EA, Korentovich MA, Zaytsev VF, Mischenko AV, Zadelenov VA, Yurchenko AA, Sherbakov DYu, Graphodatsky AS, Trifonov VA. Population genetic structure and phylogeography of sterlet (Acipenser ruthenus, Acipenseridae) in the Ob and Yenisei river basins. Mitochondrial DNA Part A, 2018, doi: 10.1080/24701394.2018.1467409

2017

1. Ilyin AA, Ryazansky SS, Doronin SA, Olenkina OM, Mikhaleva EA, Yakushev EY, Abramov YA, Belyakin SN, Ivankin AV, Pindyurin AV, Gvozdev VA, Klenov MS, Shevelyov YY. Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells. Nucleic Acids Res 45(13): 7666-7680, 2017
   (IF = 10.162)

2. Andreyeva EN, Bernardo TJ, Kolesnikova TD, Lu X, Yarinich LA, Bartholdy BA, Guo X, Posukh OV, Healton S, Willcockson MA, Pindyurin AV, Zhimulev IF, Skoultchi AI, Fyodorov DV. Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila. Genes Dev 31: 603-616, 2017
   (IF = 9.413)

3. Posukh OV, Maksimov DA, Laktionov PP, Koryakov DE, Belyakin SN. Functional dissection of Drosophila melanogaster SUUR protein influence on H3K27me3 profile. Epigenetics Chromatin 10: 56, 2017
   (IF = 5.189)

4. Giovannotti M, Trifonov VA, Paoletti A, Kichigin IG, O’Brien PCM, Kasai F, Giovagnoli G, Ng BL, Ruggeri P, Nisi Cerioni P, Splendiani A, Pereira JC, Olmo E, Rens W, Caputo Barucchi V, Ferguson-Smith MA. New insights into sex chromosome evolution in anole lizards (Reptilia, Dactyloidae). Chromosoma 126(2): 245–260, 2017
   (IF = 4.414)

5. Maksimov DA, Laktionov PP, Posukh OV, Belyakin SN, Koryakov DE. Genome-wide analysis of SU(VAR)3-9 distribution in chromosomes of Drosophila melanogaster. Chromosoma 127(1): 85-102, 2018
   (IF = 4.414)

6. Romanenko SA, Serdyukova NA, Perelman PL, Pavlova SV, Bulatova NS, Golenishchev FN, Stanyon R, Graphodatsky AS. Intrachromosomal rearrangements in rodents from the perspective of comparative region-specific painting. Genes 8(9): 215, 2017
   (IF = 3.600)

7. Proskuryakova AA, Kulemzina AI, Perelman PL, Makunin AI, Larkin DM, Farré M, Kukekova AV, Johnson JL, Lemskaya NA, Beklemisheva VR, Roelke-Parker ME, Bellizzi J, Ryder OA, O’Brien SJ, Graphodatsky AS. X chromosome evolution in Cetartiodactyla. Genes 8(9): 216, 2017
   (IF = 3.600)

8. Andreyushkova DA, Makunin AI, Beklemisheva VR, Romanenko SA, Druzhkova AS, Biltueva LB, Serdyukova NA, Graphodatsky AS, Trifonov VA. Next generation sequencing of chromosome-specific libraries sheds light on genome evolution in paleotetraploid sterlet (Acipenser ruthenus). Genes 8(11): 318, 2017
   (IF = 3.600)

9. Moskalev AА, Kudryavtseva AV, Graphodatsky AS, Beklemisheva VR, Serdyukova NA, Krutovsky KV, Sharov VV, Kulakovskiy IV, Lando AS, Kasianov AS, Kuzmin DA, Putintseva YuA, Feranchuk SI, Shaposhnikov MV, Fraifeld VE, Toren D, Snezhkina AV, Sitnik VV. De novo assembling and primary analysis of genome and transcriptome of gray whale Eschrichtius robustus. BMC Evol Biol 17(Suppl 2): 258, 2017
   (IF = 3.221)

10. Boldyreva LV, Goncharov FP, Demakova OV, Zykova TYu, Levitsky VG, Kolesnikov NN, Pindyurin AV, Semeshin VF, Zhimulev IF. Protein and genetic composition of four chromatin types in Drosophila melanogaster cell lines. Curr Genomics, 18(2): 214-226, 2017
    (IF = 1.835)

11. Zykova TYu, Levitsky VG, Belyaeva ES, Zhimulev IF. Polytene chromosomes – a portrait of functional organization of the Drosophila genome. (doi: 10.2174/1389202918666171016123830) Curr Genomics 19(3): 179-191, 2018
    (IF = 1.835)

12. Dymova MA, Zadorozhny AV, Mishukova OV, Khrapov EA, Druzhkova AS, Trifonov VA, Kichigin IG, Tishkin AA, Grushin SP, Filipenko ML. Mitochondrial DNA analysis of ancient sheep from Altai. Anim Genet 48(5): 615-618, 2017
    (IF=1.815)

13. Кулемзин СВ, Кузнецова ВВ, Мамонкин М, Таранин АВ, Горчаков АА. Основы дизайна химерных антигенных рецепторов. Acta Naturae 9(1): 6-15, 2017
    (IF = 1.667)

14. Trifonov VA, Makunin AI, Romanenko SA, Biltueva LS, Beklemisheva VR, Pobedintseva MA, Prokopov DYu, Andreyushkova DA, Graphodatsky AS. Whole genome duplications in vertebrate evolution. Mol Cytogenet 10(Suppl 1): 20(L17), 2017
    (IF = 1.455)

15. Telepova AS, Romanenko SA, Lemskaya NA, Maksimova YuV, Shorina AR, Yudkin DV. X-derived marker chromosome in patient with mosaic Turner syndrome and Dandy-Walker syndrome: a case report. Mol Cytogenet 10: 43, 2017
    (IF = 1.455)

16. Biltueva LS, Prokopov DY, Makunin AI, Komissarov AS, Kudryavtseva AV, Lemskaya NA, Vorobieva NV, Serdyukova NA, Romanenko SA, Gladkikh OL, Graphodatsky AS, Trifonov VA. Genomic organization and physical mapping of tandemly arranged repetitive DNAs in sterlet (Acipenser ruthenus). Cytogenet Genome Res 152: 148-157, 2017
    (IF = 1.354)

17. Lisachov AP, Trifonov VA, Giovannotti M, Ferguson-Smith MA, Borodin PM. Heteromorphism of “homomorphic” sex chromosomes in two Anole species (Squamata, Dactyloidae) revealed by synaptonemal complex analysis.  Cytogenet Genome Res  151: 89-95, 2017
    (IF = 1.354)

18. Poplavskaya NS, Romanenko SA, Serdyukova NA, Trifonov VA, Yang F, Nie W, Wang J, Bannikova AA, Surov AV, Lebedev VS. Karyotype evolution and phylogenetic relationships of Cricetulus sokolovi Orlov et Malygin 1988 (Cricetidae, Rodentia) inferred from chromosomal painting and molecular data. Cytogenet Genome Res 152: 65-72, 2017
    (IF = 1.354)

19. Lisachov AP, Trifonov VA, Giovannotti M, Ferguson-Smith MA, Borodin PM. Immunocytological analysis  of  meiotic  recombination  in  two  anole  lizards  (Squamata,  Dactyloidae).  Comp Cytogen 11(1): 129–141, 2017
    (IF = 1.151)

20. Кулемзин СВ, Кузнецова ВВ, Мамонкин М, Таранин АВ, Горчаков АА. CAR T-клеточная терапия: баланс эффективности и безопасности. Молекулярная биология 51(2): 274–287, 2017
    (IF = 0.799)

21. Кулемзин СВ, Чикаев НА, Волкова ОЮ, Кузнецова ВВ, Таранин АВ, Горчаков АА. Модульная система лентивирусных векторов для работы с химерными антигенными рецепторами. Биоорганическая химия 43(2): 124-132, 2017
    (IF = 0.690)

22. Druzhkova AS, Makunin AI, Vorobieva NV, Vasiliev SK, Ovodov ND, Shunkov MV, Trifonov VA, Graphodatsky AS. Complete mitochondrial genome of an extinct Equus (Sussemionus) ovodovi specimen from Denisova cave (Altai, Russia). Mitochondrial DNA Part B 2(1): 79-81, 2017

23. Гайнер ТА, Карамышева ТВ, Каримова ОГ, Корень ОЛ, Шлома ВВ, Шорина АР, Богомолов АГ, Рубцов НБ. Комплексная диагностика хромосомной патологии - деривата хромосомы 4 и малой сверхчисленной маркерной хромосомы. Медицинская генетика 16(12): 9-17, 2017

Статьи за 2014-2016