Laboratory of Comparative Genomics

Biltueva Larissa
Senior research fellow
Staff: 
thomson_logo.gif scopus_logo.jpg Biltueva Larissa senior research fellow PhD (Biology) bilaratmcb [dot] nsc [dot] ru
  scopus_logo.jpg   Totikov Azamat junior research fellow    
  scopus_logo.jpg   Tomarovsky Andrey junior research fellow    
      Lisacheva Lada research assistant    
      Modina Svetlana research assistant    
      Yakovlev Artem research assistant    

Former research workers:

Andreyushkova Daria
Bishani Ali
Dementieva Polina, PhD
Kichigin Ilya
Kliver Sergei, PhD
Pobedintseva Maria, PhD
Rumyantsev Aleksander		 Popova Kseniya
Sarachakov Aleksandr
Tishakova Katerina
Trifonov Vladimir, DSc
Utkin Yaroslav
Vlassov Evgeny
Vorobieva Nadezhda, PhD

Research: 
  • Structure of supernumerary chromosomes
  • System of chromosomal sex determination
IMCB_DNA_Zoo.JPG

The staff of the Laboratory are among the contributors of a large international consortium DNA Zoo
Recent publications: 

  1. Lisachova LS, Lisachov AP, Ermakov OA, Svinin AO, Chernigova PI, Lyapkov SM, Zamaletdinov RI, Pavlov AV, Zaks SS, Fayzulin AI, Korzikov VA, Simonov E. Continent-wide distribution of CMTV-like ranavirus, from the Urals to the Atlantic Ocean. Ecohealth, 2025, doi: 10.1007/s10393-025-01703-3

  2. Lisachova L, Lisachov A, Romanenko S, Davletshina G, Altmanová M, Rovatsos M, Kratochvíl L, Giovannotti M, Nazarov R, Okshtein I, Trifonov V. Concerted evolution of genus-specific centromeric satellite DNA in Eremias (Lacertidae, Reptilia). Cytogenet Genome Res, 2025, doi: 10.1159/000543883

  3. Modina SA, Kusliy MA, Malikov DG, Molodtseva AS.  Phylogeography of the woolly mammoth (Mammuthus primigenius) in the Minusinsk Depression of southern Siberia in the Late Pleistocene. (doi: 10.18699/vjgb-24-63) Vavilov Journal of Genetics and Breeding 28(5): 571-577, 2024

  4. Sandoval-Velasco M, ... Kusliy MA, Romanenko SA, Lemskaya NA, Serdyukova NA, Modina SA, Perelman PL, ... Graphodatsky AS, ... Aiden EL. Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample. (doi: 10.1016/j.cell.2024.06.002) Cell 187(14): 3541-3562.e51, 2024

  5. Askeyev IV, Askeyev OV, Askeyev AO, Shaymuratova DN, Monakhov SP, Pobedintseva MA, Trifonov VA, Górski K, Schletterer M. Archaeozoology supports a holistic view on fish assessments in large rivers—A case study from the Volga river: From quantitative data and ancient DNA to biodiversity analysis. (doi: 10.3390/w16081109) Water 16(8): 1109, 2024 

  6. Trifonov VA. Book review: Small supernumerary marker chromosomes. Basics. (doi: 10.21926/obm.genet.2402224) OBM Genetics 8(2): 224, 2024

  7. Romanenko SA, Malikov VG, Mahmoudi A, Golenishchev FN, Lemskaya NA, Pereira JC, Trifonov VA, Serdyukova NA, Ferguson-Smith MA, Aliabadian  Mansour, Graphodatsky AS. New data on comparative cytogenetics of the mouse-like hamsters (Calomyscus Thomas, 1905) from Iran and Turkmenistan. In: The Stability and Evolution of Genes and Genomes (eds. Viggiano L, Marsano RM), MDPI, Basel, Switzerland, 2024, pp 56-72 (doi: 10.3390/books978-3-0365-9802-4)

  8. Kononova Y, Adamenko L, Kazachkova E, Solomatina M, Romanenko S, Proskuryakova A, Utkin Y, Gulyaeva M, Spirina A, Kazachinskaia E, Palyanova N, Mishchenko O, Chepurnov A, Shestopalov A. Features of SARS-CoV-2 replication in various types of reptilian and fish cell cultures. (doi: 10.3390/v15122350) Viruses 15(12): 2350, 2023

  9. Romanenko SA, Kliver SF, Serdyukova NA, Perelman PL, Trifonov VA, Seluanov A, Gorbunova V, Azpurua J, Pereira JC, Ferguson-Smith MA, Graphodatsky AS. Integration of fluorescence in situ hybridization and chromosome-length genome assemblies revealed synteny map for guinea pig, naked mole-rat, and human. (doi: 10.1038/s41598-023-46595-x) Sci Rep 13: 21055, 2023

  10. Lisachov A, Tishakova K, Romanenko S, Lisachova L, Davletshina G, Prokopov D, Kratochvíl L, O'Brien P, Ferguson-Smith M, Borodin P, Trifonov V. Robertsonian fusion triggers recombination suppression on sex chromosomes in Coleonyx geckos. (doi: 10.1038/s41598-023-39937-2) Sci Rep 13: 15502, 2023

  11. Kliver S, Houck ML, Perelman PL, Totikov A, Tomarovsky A, Dudchenko O, Omer AD, Colaric Z, Weisz D, Aiden EL, Chan S, Hastie A, Komissarov A, Ryder OA, Graphodatsky A, Johnson WE, Maldonado JE, Pukazhenthi BS, Marinari PE, Wildt DE, Koepfli K-P. Chromosome-length genome assembly and karyotype of the endangered black-footed ferret (Mustela nigripes). (doi: 10.1093/jhered/esad035) J Heredity 114(5): 539-548, 2023

  12. Kusliy MA, Yurlova AA, Neumestova AI, Vorobieva NV, Gutorova NV, Molodtseva AS, Trifonov VA, Popova KO, Polosmak NV, Molodin VI, Vasiliev SK, Semibratov VP, Iderkhangai T-O, Kovalev AA, Erdenebaatar D, Graphodatsky AS, Tishkin AA. Genetic history of the Altai breed horses: from ancient times to modernity. (doi: 10.3390/genes14081523) Genes 14(8): 1523, 2023

  13. Biltueva LS, Vorobieva NV, Lemskya NA, Perelman PL, Trifonov VA, Panov VV, Abramov AV, Kawada S-i, Serdukova NA, Graphodatsky AS. Chromosomal evolution of the Talpinae. (doi: 10.3390/genes14071472) Genes 14(7): 1472, 2023

  14. Yakupova A, Tomarovsky A, Totikov A, Beklemisheva V, Logacheva M, Perelman PL, Komissarov A, Dobrynin P, Krasheninnikova K, Tamazian G, Serdyukova NA, Rayko M, Bulyonkova T, Cherkasov N, Pylev V, Peterfeld V, Penin A, Balanovska E, Lapidus A, Consortium DZ, O'Brien SJ, Graphodatsky A, Koepfli K-P, Kliver S. Chromosome-length assembly of the Baikal seal (Pusa sibirica) genome reveals a historically large population prior to isolation in lake Baikal. (doi: 10.3390/genes14030619) Genes 14(3): 619, 2023

  15. Beklemisheva VR, Lemskaya NA, Prokopov DY, Perelman PL, Romanenko SA, Proskuryakova AA, Serdyukova NA, Utkin YA, Nie W, Ferguson-Smith MA, Fentang Y, Graphodatsky AS. Maps of constitutive-heterochromatin distribution for four martes species (Mustelidae, Carnivora, Mammalia) show the formative role of macrosatellite repeats in interspecific variation of chromosome structure. (doi: 10.3390/genes14020489) Genes 14(2): 489, 2023

  16. Lisachov A, Rumyantsev A, Prokopov D, Ferguson-Smith M, Trifonov V. Conservation of major satellite DNAs in snake heterochromatin. (doi: 10.3390/ani13030334) Animals 13(3): 334, 2023

  17. Dumas F, Perelman PL, Biltueva L, Roelke M. Retrotransposon mapping in spider monkey genomes of the family Atelidae (Platyrrhini, Primates) shows a high level of LINE-1 amplification. (doi: 10.4081/jbr.2022.10725) J Biol Res 95(2): 10725, 2022

  18. Interesova EA, Babkina IB, Romanov VI, Pozdnyak IV, Davletshina GI, Trifonov VA. New data on small lampreys of the genus Lethenteron (Petromyzontidae) of the Tom river, a typical habitat of the Siberian brook lamprey Lethenteron kessleri. (doi: 10.1134/S003294522206011X) J Ichthyol 62(7): 1230-1236, 2022

  19. Karamysheva TV, Gayner TA, Elisaphenko EA, Trifonov VA, Zakirova EG, Orishchenko KE, Prokhorovich MA, Lopatkina ME, Skryabin NA, Lebedev IN, Rubtsov NB. The Precise breakpoint mapping in paracentric inversion 10q22.2q23.3 by comprehensive cytogenomic analysis, multicolor banding, and single-copy chromosome sequencing. (doi.org/10.3390/biomedicines10123255) Biomedicines 10(12): 3255, 2022

  20. Tishakova KV, Prokopov DY, Davletshina GI, Rumyantsev AV, O’Brien PCM, Ferguson-Smith MA, Giovannotti M, Lisachov AP, Trifonov VA. Identification of Iguania ancestral syntenic blocks and putative sex chromosomes in the veiled chameleon (Chamaeleo calyptratus, Chamaeleonidae, Iguania). (doi: 10.3390/ijms232415838) Int J Mol Sci 23(24): 15838, 2022

  21. Ochkalova S, Korchagin V, Vergun A, Urin A, Zilov D, Ryakhovsky S, Girnyk A, Martirosyan I, Zhernakova DV, Arakelyan M, Danielyan F, Kliver S, Brukhin V, Komissarov A, Ryskov A. First genome of rock lizard Darevskia valentini involved in formation of several parthenogenetic species. (doi: 10.3390/genes13091569) Genes 13(9): 1569, 2022

  22. Romanenko SA, Prokopov DY, Proskuryakova AA, Davletshina GI, Tupikin AE, Kasai F, Ferguson-Smith MA, Trifonov VA. The cytogenetic map of the Nile crocodile (Crocodylus niloticus, Crocodylidae, Reptilia) with fluorescence in situ localization of major repetitive DNAs. (doi: 10.3390/ijms232113063) Int J Mol Sci 23(21): 13063, 2022

  23. Romanenko S, Trifonov V. Chapter 3. Generation of microdissection-derived painting probes from single copy chromosomes. In: Liehr T (ed.) Cytogenetics and Molecular Cytogenetics, CRC Press, Boca Raton, FL, USA, 2022, pp 27-34 (doi: 10.1201/9781003223658)

  24. Milioto V, Perelman PL, Paglia LL, Biltueva L, Roelke M, Dumas F. Mapping retrotransposon LINE-1 sequences into two Cebidae species and Homo sapiens genomes and a short review on primates. (doi: 10.3390/genes13101742) Genes 13(10): 1742, 2022

  25. Interesova EA, Romanov VI, Davletshina GI, Fedorova VS, Trifonov VA. Dissemination of Misgurnus nikolskyi (Cobitidae) in the south of Western Siberia. (doi: 10.1134/S2075111722030067) Russ J Biol Invasions 13(3): 301-304, 2022

  26. de Ferran V, ..., Kliver S, Serdyukova N, ..., Eizirik E. Phylogenomics of the world’s otters. (doi: 10.1016/j.cub.2022.06.036) Curr Biol 32(16): 3650-3658.e4, 2022

  27. Derežanin L, Blažytė A, Dobrynin P, Duchêne DA, Grau JH, Jeon S, Kliver S, Koepfli K-P, Meneghini D, Preick M, Tomarovsky A, Totikov A, Fickel J, Förster DW. Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae. (doi: 10.1111/mec.16443) Mol Ecol 31(10): 2898-2919, 2022

  28. Molodtseva AS, Makunin AI, Salomashkina VV, Kichigin IG, Vorobieva NV, Vasiliev SK, Shunkov MV, Tishkin AA, Grushin SP, Anijalg P, Tammeleht E, Keis M, Boeskorov GG, Mamaev N, Okhlopkov IM, Kryukov AP, Lyapunova EA, Kholodova MV, Seryodkin IV, Saarma U, Trifonov VA, Graphodatsky AS. Phylogeography of ancient and modern brown bears from eastern Eurasia. (doi: 10.1093/biolinnean/blac009) Biol J Linn Soc 135(4): 722-733, 2022

  29. Rajičić M, Makunin A, Adnađević T, Trifonov V, Vujošević M, Blagojević J. B chromosomes’ sequences in yellow-necked mice Apodemus flavicollis — exploring the transcription. (doi: 10.3390/life12010050) Life 12(1): 50, 2022

Publications for previous years

Selected talks: 

  1. Modina SA. Phylogeography of Late Pleistocene woolly mammoths (Mammuthus primigenius) from geographically isolated areas of southern and eastern Siberia. VII Congress of the Serbian Genetic Society, 2-5 October 2024, Zlatibor, Serbia

  2. Trifonov V. Origin and evolution of mammalian B chromosomes. 4th B Chromosome Conference. 20-23 July 2019, Botucatu, Brazil

  3. Trifonov VA. Polyploidy and genome evolution of ray-finned fishes. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  4. Kichigin IG. Studying anolis and gekkota sex chromosomes by isolated chromosome sequencing. International Conference “Chromosome – 2018”, 20-24 August 2018, Novosibirsk, Russia

  5. Trifonov V. Evolutionary sex chromosome translocations in amniotes. 23rd International Colloquium on Animal Cytogenetics and Genomics, June 9-12, 2018, Saint-Petersburg, Russia

  6. Trivonof V. Whole genome duplications in vertebrate evolution. 11th European Cytogenetics Conference, 1-4 July 2017, Florence, Italy

  7. Trifonov V. Evolutionary plasticity of sturgeon genomes. 21st International Chromosome Conference. 10-13 July 2016, Foz do Iguaçu, Brazil

  8. Trifonov VA. Application of molecular cytogenetic technologies for the study of sex chromosomes. Meeting intended to facilitate design of strategies to study the impact of mitonuclear incompatibilities in the diversification of animals. 14-16 October 2015, University of A Coruña, Spain

  9. Trifonov VA. Molecular composition and evolution of cervid B chromosomes. 3rd B-Chromosome Conference, 7-9 April 2014, Gatersleben, Germany

  10. Trifonov VA. Amplification of genes on mammalian B chromosomes. The 19th International Chromosome Conference. 2-6 September 2013, Bologna, Italy

  11. Biltueva LS. Karyotype evolution of Eulipotyphla. The genome homology of Sorex species revealed by comparative chromosome painting and banding data. VIth European Congress of Mammology, 19-23 July 2011, Paris, France

  12. Trifonov VA. Amplification of genes on mammalian B chromosomes. Second Conference of Brazilian Cytogenetics, 28-30 August 2011, Aguas de Lindoia, Brazil

  13. Trifonov VA. Isolation and analysis of coding sequences from B-chromosomes of the Red Fox (Vulpes vulpes) and Siberian Roe Deer (Capreolus pygargus). 2nd Congress of the International Cytogenetics and Genome Society and Digital Scientific UK Users Group Meeting, 25-29 June 2006, Canterbury, UK

  14. Biltueva L. Karyotypic relationships in the Insectivora. The 8th Meeting of the International Sorex araneus Cytogenetic Committee (ISACC). 8-12 August 2008, York, UK

Collaboration: 

  • Cambridge Resource Centre for Comparative Genomics, University of Cambridge, UK

  • National Cancer Institute at Frederick, MD, USA

  • Cornell University, Ithaca, NY, USA

  • University of North Carolina at Chapel Hill, NC, USA

  • Institut für Humangenetik, Jena, Germany

  • Julius-Maximilians-Universität Würzburg, Germany

  • Muséum national d'histoire naturelle, Paris, France

  • Università degli Studi di Firenze, Florence, Italy

  • Università Politécnica delle Marche, Ancona, Italy

  • Kunming Institute of Zoology, China

  • Zhejiang Ocean University, China

  • Universidade de São Paulo, Câmpus de Rio Claro, Brasil

  • Universidade Estadual Paulista, São Paulo, Brazi

  • Universidade Federal de Minas Gerais, Belo Horizonte, Brasil

  • Institute for Biological Research "Siniša Stanković", Belgrade, Serbia

  • Univerzita Karlova, Praha, Czech Republick

Research Groups

Department of Structure and Function of Chromosomes
Department of Regulation of Genetic Processes