Department of Molecular Immunology

Laboratory of Immunogenetics

Taranin Alexander
Head of the Department
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Taranin Alexander head DSc (Biology) taraninatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Volkova Olga senior research fellow PhD (Biology) volkovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Mechetina Lyudmila senior research fellow PhD (Biology) lucieatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Najakshin Alexander senior research fellow PhD (Biology) najakshinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Chikaev Nikolay senior research fellow PhD (Biology) na_chikatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Baranov Konstantin senior research fellow PhD (Biology) baranovatmcb [dot] nsc [dot] ru
      Mayerova Anna engineer   maerovaatmcb [dot] nsc [dot] ru
      Chernishova Zoya lab technician   z_chernishovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Solodkov Pavel part-time research assistant    
      Murasheva Svetlana part-time research assistant    

Former research workers:

Belovezhets Tatiana
Brusentsov Ilya
Chernikova Daria
Chikaev Anton, PhD
Guselnikov Sergey, PhD
Gorchakov Andrey, PhD
Istomina Polina
Khantakova Daria
Kulemzin Sergey, PhD
Kuznetsova Valeria
Matvienko Daria
Reshetnikova Evdokia
Shershneva Daria
Sizentsova Yana
Sokratyan Arpine
Starikovskaya Antonina
Yurina Anna

Research: 
EuroMabNet.png

The staff of the Laboratory are participants of EuroMAbNet - the European network of laboratories working in the field of monoclonal antibodies

Recent publications: 
  1. Solodkov PP, Najakshin AM, Chikaev NA, Kulemzin SV, Mechetina LV, Baranov KO, Guselnikov SV, Gorchakov AA, Belovezhets TN, Chikaev AN, Volkova OY, Markhaev AG, Kononova YuV, Alekseev AY, Gulyaeva MA, Shestopalov AM, Taranin AV. Serial llama immunization with various SARS-CoV-2 RBD variants induces broad spectrum virus-neutralizing nanobodies. (doi: 10.3390/vaccines12020129Vaccines 12(2): 129, 2024

  2. Kulemzin SV, Guselnikov SV, Nekrasov BG, Molodykh SV, Kuvshinova IN, Murasheva SV, Belovezhets TN, Gorchakov AA, Chikaev AN, Chikaev NA, Volkova OY, Yurina AA, Najakshin AM, Taranin AV. Hybrid immunity from Gam-COVID-Vac vaccination and natural SARS-CoV-2 infection confers broader neutralizing activity against omicron lineage VOCs than revaccination or reinfection. (doi: 10.3390/vaccines12010055) Vaccines 12(1): 55, 2024

  3. Sukhova M, Byazrova M, Mikhailov A, Yusubalieva G, Maslova I, Belovezhets T, Chikaev N, Vorobiev I, Baklaushev V, Filatov A. Humoral immune responses in patients with severe COVID-19: a comparative pilot study between individuals infected by SARS-CoV-2 during the wild-type and the delta periods. (doi: 10.3390/microorganisms11092347) Microorganisms 11(9): 2347, 2023

  4. Aripov VS, Volkova NV, Taranin AV, Mechetina LV, Chikaev NA, Nayakshin AM, Nesmeyanova VS, Isaeva AA, Merkul'eva YA, Shanshin DV, Belenkaya SV, Ilyichev AA, Shcherbakov DN. The Search for single-domain antibodies interacting with the receptor-binding domain of SARS-CoV-2 surface protein. (doi: 10.1007/s10517-023-05839-6) Bull Exp Biol Med 175(2): 225-228, 2023

  5. Belovezhets T, Kulemzin S, Volkova O, Najakshin A, Taranin A, Gorchakov A. Comparative pre-clinical analysis of CD20-specific CAR T cells encompassing 1F5-, Leu16-, and 2F2-based antigen-recognition moieties. (doi: 10.3390/ijms24043698) Int J Mol Sci 24(4): 3698, 2023

  6. Byazrova MG, Astakhova EA, Minnegalieva AR, Sukhova MM, Mikhailov AA, Prilipov AG, Gorchakov AA, Filatov AV. Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination. (doi: 10.1038/s41541-022-00566-x) npj Vaccines 7(1): 145, 2022

  7. Yusubalieva GM, Dashinimaev EB, Gorchakov AA, Kulemzin SV, Brovkina OA, Kalinkin AA, Vinokurov AG, Shirmanova MV, Taranin AV, Baklaushev VP. Enhanced natural killers with CISH and B2M gene knockouts reveal increased cytotoxicity in glioblastoma primary cultures. (doi: 10.1134/S0026893322050156) Mol Biology 56(5): 770-779, 2022

  8. Astakhova EA, Byazrova MG, Yusubalieva GM, Kulemzin SV, Kruglova NA, Prilipov AG, Baklaushev VP, Gorchakov AA, Taranin AV, Filatov AV. Functional profiling of in vitro reactivated memory B cells following natural SARS-CoV-2 infection and Gam-COVID-Vac vaccination. (doi: 10.3390/cells11131991Cells 11(13): 1991, 2022

  9. Kulemzin SV, Sergeeva MV, Baranov KO, Gorchakov AA, Guselnikov SV, Belovezhets TN, Volkova OY, Najakshin AM, Chikaev NA, Danilenko DM, Taranin AV. VH3-53/66-Class RBD-specific human monoclonal antibody iB20 displays cross-neutralizing activity against emerging SARS-CoV-2 lineages. (doi: 10.3390/jpm12060895J Pers Med 12(6): 895, 2022

  10. Jakovleva TV, Kazantseva AYu, Dubinina AD, Balybina NYu, Baranov KO, Makarova EN, Bazhan NM. Estradiol-dependent and independent effects of FGF21  in obese female mice. (doi: 10.18699/VJGB-22-20) Vavilov J Genet Breed 26(2): 159-168, 2022

  11. Zaboronok A, Khaptakhanova P, Uspenskii S, Bekarevich R, Mechetina L, Volkova O, Mathis BJ, Kanygin V, Ishikawa E, Kasatova A, Kasatov D, Shchudlo I, Sycheva T, Taskaev S, Matsumura A. Polymer-stabilized elemental boron nanoparticles for boron neutron capture therapy: Initial irradiation experiments. (doi: 10.3390/pharmaceutics14040761Pharmaceutics 14(4): 761, 2022

  12. Bazhan SI, Antonets DV, Starostina EV, Ilyicheva TN, Kaplina ON, Marchenko VYu, Volkova OYu, Bakulina AYu, Karpenko LI. In silico design of influenza a virus artificial epitope-based T-cell antigens and the evaluation of their immunogenicity in mice. (doi: 10.1080/07391102.2020.1845978) J Biomol Struct Dyn 40(7): 3196-3212, 2022

  13. Borgoyakova MB, Karpenko LI, Rudometov AP, Volosnikova EA, Merkuleva IA, Starostina EV, Zadorozhny AM, Isaeva AA, Nesmeyanova VS, Shanshin DV, Baranov KO, Volkova NV, Zaitsev BN, Orlova LA, Zaykovskaya AV, Pyankov OV, Danilenko ED, Bazhan SI, Shcherbakov DN, Taranin AV, Ilyichev AA. Self-assembled particles combining SARS-CoV-2 RBD protein and RBD DNA vaccine induce synergistic enhancement of the humoral response in mice. (doi: 10.3390/ijms23042188Int J Mol Sci 23(4): 2188, 2022
  14. Byazrova MG, Kulemzin SV, Astakhova EA, Belovezhets TN, Efimov GA, Chikaev AN, Kolotygin IO, Gorchakov AA, Taranin AV, Filatov AV. Memory B cells induced by Sputnik V vaccination produce SARS-CoV-2 neutralizing antibodies upon ex vivo restimulation. (doi: 10.3389/fimmu.2022.840707Front Immunol 13: 840707, 2022

  15. Smagin DA, Kovalenko IL, Galyamina AG, Belozertseva IV, Tamkovich NV, Baranov KO, Kudryavtseva NN. Chronic lithium treatment affects anxious behaviors and the expression of serotonergic genes in midbrain raphe nuclei of defeated male mice. (doi: 10.3390/biomedicines9101293Biomedicines 9(10): 1293, 2021

  16. Makarova E, Kazantseva A, Dubinina A, Jakovleva T, Balybina N, Baranov K, Bazhan N. The same metabolic response to FGF21 administration in male and female obese mice is accompanied by sex-specific changes in adipose tissue gene expression. (doi: 10.3390/ijms221910561Int J Mol Sci 22(19): 10561, 2021

  17. Makarova E, Kazantseva A, Dubinina A, Denisova E, Jakovleva T, Balybina N, Bgatova N, Baranov K, Bazhan N. Fibroblast growth factor 21 (FGF21) administration sex-specifically affects blood insulin levels and liver steatosis in obese Ay mice. (doi: 10.3390/cells10123440Cells 10(12): 3440, 2021

  18. Kulemzin S, Evsyukov I, Belovezhets T, Taranin A, Gorchakov A. Horses for courses in the era of CARs: Advancing CAR T and CAR NK cell therapies. (doi: 10.3390/jpm11111182J Pers Med 11(11): 1182, 2021

  19. Gorchakov AA, Kulemzin SV, Guselnikov SV, Baranov KO, Belovezhets TN, Mechetina LV, Volkova OYu, Najakshin AM, Chikaev NA, Chikaev AN, Solodkov PP, Larichev VF, Gulyaeva MA, Markhaev AG, Kononova YuV, Alekseyev AYu, Shestopalov AM, Yusubalieva GM, Klypa TV, Ivanov AV, Valuev-Elliston VT, Baklaushev VP, Taranin AV. Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern. (doi: 10.1038/s41421-021-00340-8Cell Discov 7: 96, 2021

  20. Zaboronok A, Taskaev S, Volkova O, Mechetina L, Kasatova A, Sycheva T, Nakai K, Kasatov D, Makarov A, Kolesnikov I, Shchudlo I, Bykov T, Sokolova E, Koshkarev A, Kanygin V, Kichigin A, Mathis BJ, Ishikawa E, Matsumura A. Gold nanoparticles permit in situ absorbed dose evaluation in boron neutron capture therapy for malignant tumors. (doi: 10.3390/pharmaceutics13091490Pharmaceutics 13(9): 1490, 2021

  21. Smagina AS, Kulemzin SV, Yusubalieva GM, Kedrova AG, Sanzharov AE, Ivanov YV, Matvienko DA, Kalsin VA, Gorchakov AA, Baklaushev VP, Taranin AV. VAV1‐overexpressing YT cells display improved cytotoxicity against malignant cells. (doi: 10.1002/bab.2001) Biotechnol Appl Biochem 68(4): 849-855, 2021

  22. Starostina EV, Sharabrin SV, Antropov DN, Stepanov GA, Shevelev GYu, Lemza AE, Rudometov AP, Borgoyakova MB, Rudometova NB, Marchenko VYu, Danilchenko NV, Chikaev AN, Bazhan SI, Ilyichev AA, Karpenko LI. Construction and immunogenicity of modified mRNA-vaccine variants encoding influenza virus antigens (doi: 10.3390/vaccines9050452Vaccines 9(5): 452, 2021

  23. Byazrova M, Yusubalieva G, Spiridonova A, Efimov G, Mazurov D, Baranov K, Baklaushev V, Filatov A. Pattern of circulating SARS-CoV-2-specific antibody-secreting and memory B-cell generation in patients with acute COVID-19. (doi: 10.1002/cti2.1245) Clin Transl Immunology 10(2): e1245, 2021

  24. Uspenskii SA, Khaptakhanova PA, Zaboronok AA, Kurkin TS, Volkova OYu, Mechetina LV, Taranin AV, Kanygin VV, Matsumura A, Taskaev SYu. Elemental boron nanoparticles: production by ultrasonication in aqueous medium and application in boron neutron capture therapy. (doi: 10.1134/S0012500820030027) Dokl Chem 491: 45-48, 2020

  25. Gorchakov AA, Kulemzin SV, Kochneva GV, Taranin AV. Challenges and prospects of chimeric antigen receptor T-cell therapy for metastatic prostate cancer. (doi: 10.1016/j.eururo.2019.08.014Eur Urol 77(3): 299-308, 2020

  26. Kochneva GV, Sivolobova GF, Tkacheva AV, Gorchakov AA, Kulemzin SV. Combination of oncolytic virotherapy and CAR T/NK cell therapy for the treatment of cancer. (doi: 10.1134/S0026893320010100) Mol Biol 54(1): 1-12, 2020

Publications for previous years

Selected talks: 
  1. Gorchakov A. Adnectin-based CARs: pros and cons. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  2. Chikaev A. CD47/SIRPa blockers and CARs: together we stand. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  3. Belovezhets T. Quest for the optimal NK-cell line as a CAR carrier. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  4. Kulemzin S. Forging the Natural Killer with genome editing. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  5. Kulemzin SV. Generation of NK-cell lines with enhanced therapeutic potential. International congress “CRISPR-2018”, September 10-14, 2018, Novosibirsk, Russia

  6. Matvienko D. PSMA- and PSCA-specific chimeric antigen receptors (CARs) for prostate cancer therapy. The 25th International Students Congress of bio(Medical) Science (ISCOMS 2018) 4-8 June 2018, Groningen, Netherlands

  7. Gorchakov A. Optimal CAR design and development of an ECAR NK cell platform. XI Raisa Gorbacheva Memorial Meeting “Hematopoetic Stem Cell Transplantation. Gene and Cellular Therapy”, Workshop on Genome Editing in Hematology & HSCT, 14-16 September 2017, St. Petersburg, Russia

  8. Mechetina L. Artificial antibodies based on human 10Fn3 scaffold. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  9. Baranov K. Multimeric 10Fn3-based proteins as inductors of anti-idiotypic antibodies. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  10. Taranin AV. Dot immunoenzyme assay for the diagnosis of Aleutian mink disease. XIth International Scientific Congress in Fur Animal Production. 23-26 August 2016, Helsinki, Finland

  11. Mechetina LV. New intacellular B cell marker FCRLA. 5th EuroMabNet meeting, 23-24 September 2013, Menorca, Spain

  12. Mechetina L. FCRL6 receptor: expression and associated proteins. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  13. Baranov KO. Searching for ligands of the FcR-like B cell-specific receptors. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  14. Taranin A. Molecular Evolution of the FcR- and KIR-like Receptors in Tetrapods. ISDCI 10th International Congress,
    1-6 July 2006, Charleston, USA

  15. Guselnikov S. Evolution of FcR- and KIR-like leukocyte receptors: from Teleostei to Mammalia. Eastern Great Lakes Molecular Evolution Meeting. Koffler Institute for Pharmacy Management, University of Toronto, 30 April 2005, Toronto, Canada

Collaboration: 
  • University of Alabama at Birmingham, AL, USA

  • University of Rochester Medical Center, NY, USA

  • Universitat de Barcelona, Spain

  • Faculty of Medicine, University of Tsukuba, Japan