Laboratory of Immunogenetics

Taranin Alexander
Head of the Laboratory

Staff: 
      Name Position Academic
degree
Contacts
thomson_logo.gif scopus_logo.jpg Taranin Alexander head DSc (Biology) taraninatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Volkova Olga senior research fellow PhD (Biology) volkovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Mechetina Lyudmila senior research fellow PhD (Biology) lucieatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Najakshin Alexander senior research fellow PhD (Biology) najakshinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Chikaev Nikolay senior research fellow PhD (Biology) na_chikatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Guselnikov Sergey senior research fellow PhD (Biology) sguselnikovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Gorchakov Andrey senior research fellow PhD (Biology) gorchakovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Kulemzin Sergey senior research fellow PhD (Biology) skulemzinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Baranov Konstantin senior research fellow PhD (Biology) baranovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Chikaev Anton research fellow PhD (Biology) chikaevatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Reshetnikova Evdokia junior research fellow   ereshetatmcb [dot] nsc [dot] ru
      Sizentsova Yana research assistant    
      Belovezhets Tatiana research assistant    
      Matvienko Daria research assistant    
      Mayerova Anna engineer    
      Starikovskaya Antonina lab technician    
      Chernishova Zoya lab technician   z_chernishovaatmcb [dot] nsc [dot] ru
      Chernikova Daria      

Former research workers

Kuznetsova Valeria
Sokratyan Arpine

Research: 
EuroMabNet.png

The staff of the Laboratory are participants of EuroMAbNet - the European network of laboratories working in the field of monoclonal antibodies

Recent publications: 
  1. Reshetnikova E, Guselnikov S, Volkova O, Baranov K, Taranin A, Mechetina L. B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans. Cytometry B Clin Cytom, 2018, doi: 10.1002/cyto.b.21611

  2. Kulemzin SV, Gorchakov AA, Chikaev AN, Kuznetsova VV, Volkova OY, Matvienko DA, Petukhov AV, Zaritskey AY, Taranin AV. VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cells. (doi: 10.18632/oncotarget.24078) Oncotarget 9(10): 9021-9029, 2018

  3. Koval O, Volkova O, Kulemzin S, Gorchakov A, Tkachenko A, Nushtaeva A, Kuligina E, Richter V, Taranin A. NK-cell based delivery of anticancer therapeutics. (doi: 10.1093/annonc/mdx711.050) Annals Oncology 28(Suppl 11): 69P, 2017

  4. Gorchakov A, Kulemzin S, Kuznetsova V, Volkova O, Taranin A. FnCARs: a platform expanding the repertoire of proteins targetable with chimeric antigen receptors. Mol Therapy 25(5S1): 272, 2017

  5. Zaboronok AA, Byvaltsev VA, Kanygin VV, Iarullina AI, Kichigin AI, Taranin AV, Volkova OYu, Mechetina LV, Taskaev SYu, Muhamadiyarov RA, Zavyalov EL, Nakai K, Sato E, Yamamoto T, Mathis BJ, Matsumura A. Boron-neutron capture therapy in Russia: preclinical evaluation of efficacy and perspectives of its application in neuro-oncology. New Armenian Med J 11(1): 6-15, 2017

  6. Sherin PS, López-Duarte I, Dent MR, Kubánková M, Vyšniauskas A, Bull JA, Reshetnikova ES, Klymchenko AS, Tsentalovich YP, Kuimova MK. Visualising the membrane viscosity of porcine eye lens cells using molecular rotors. Chem Sci 8: 3523-3528, 2017

  7. Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov AA. CAR T-cell therapy: Balance of efficacy and safety. Mol Biology 51(2): 237–250, 2017

  8. Kulemzin SV, Chikaev NA, Volkova OY, Kuznetsova VV, Taranin AV, Gorchakov AA. Modular lentiviral vector system for chimeric antigen receptor design optimization. Rus J Bioorg Chem 43(2): 107-114, 2017

  9. Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov АA. Engineering chimeric antigen receptors. Acta Naturae 9(1): 6-14, 2017

  10. Sokratian A, Baranov K, Guselnikov S, Chikaev N, Volkova O, Mechetina L, Taranin A, Gorchakov A , Kulemzin S. Identification of the human SLAMF9-receptor complex. Tissue Antigens 85: 381-382, 2015

  11. Guselnikov SV, Grayfer L, De Jesús Andino F, Rogozin IB, Robert J, Taranin AV. Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis. Dev Comp Immunol 53: 158-168, 2015

  12. Romanets-Korbut O, Najakshin AM, Yurchenko M, Malysheva TA, Kovalevska L, Shlapatska LM, Zozulya YA, Taranin AV, Horvat B, Sidorenko SP. Expression of CD150 in tumors of the central nervous system: identification of a novel isoform. PLoS One 10(2): e0118302, 2015

  13. Reguzova AY, Karpenko LI, Mechetina LV, Belyakov IM. Peptide–MHC multimer-based monitoring of CD8 T-cells in HIV-1 infection and AIDS 5 vaccine development. Expert Rev Vaccines 14: 69-84, 2015

  14. Volkova O, Guselnikov S, Mechetina L, Chikaev N, Baranov K, Kulemzin S, Reshetnikova E, Najakshin A, Taranin A. Development and characterization of domain-specific monoclonal antibodies produced against human SLAMF9. Monoclon Antib Immunodiagn Immunother 33: 209-214, 2014

  15. Alekseyenko AA, Gorchakov AA, Zee BM, Fuchs SM, Kharchenko PV, Kuroda MI. Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. Genes Dev 28: 1445-1460, 2014

  16. Alekseyenko AA, Gorchakov AA, Kharchenko PV, Kuroda MI. Reciprocal interactions of human C10orf12 and C17orf96 with PRC2 revealed by BioTAP-XL cross-linking and affinity purification. Proc Natl Acad Sci USA 111: 2488–2493, 2014

  17. Kulemzin S, Chikaev N, Volkova O, Reshetnikova E, Taranin A, Najakshin A, Mechetina L. Characterization of human FCRLA isoforms. Immunol Lett 152: 153-158, 2013

  18. Pomaznoy M, Tatkov S, Katokhin A, Afonnikov D, Babenko V, Furman D, Brusentsov I, Belavin P, Najakshin A, Guselnikov S, Vasiliev G, Sivkov A, Prokhortchouk E, Skryabin K, Mordvinov V. Adult Opisthorchis felineus major protein fractions deduced from transcripts: Comparison with liver flukes Opisthorchis viverrini and Clonorchis sinensis. Exp Parasitol 135: 297-306, 2013

  19. Zhou Q, Ellison CE, Kaiser VB, Alekseyenko AA, Gorchakov AA, Bachtrog D. The epigenome of evolving Drosophila neo-sex chromosomes: Dosage compensation and heterochromatin formation. PLoS Biol 11 (11): e1001711, 2013. doi: 10.1371/journal.pbio.1001711

  20. Alekseyenko AA, Ellison CE, Gorchakov AA, Zhou Q, Kaiser VB, Toda N, Walton Z, Peng S, Park PJ, Bachtrog D, Kuroda MI. Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila. Genes Dev 27: 853-858, 2013

  21. Wang CI, Alekseyenko AA, LeRoy G, Elia AEH, Gorchakov AA, Britton LMP, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nat Struct Mol Biol 20: 202-209, 2013

Selected talks: 
  1. Gorchakov A. Optimal CAR design and development of an ECAR NK cell platform. XI Raisa Gorbacheva Memorial Meeting “Hematopoetic Stem Cell Transplantation. Gene and Cellular Therapy”, Workshop on Genome Editing in Hematology & HSCT, 14-16 September 2017, St. Petersburg, Russia

  2. Mechetina L. Artificial antibodies based on human 10Fn3 scaffold. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  3. Baranov K. Multimeric 10Fn3-based proteins as inductors of anti-idiotypic antibodies. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  4. Mechetina LV. New intacellular B cell marker FCRLA. 5th EuroMabNet meeting, 23-24 September 2013, Menorca, Spain

  5. Mechetina L. FCRL6 receptor: expression and associated proteins. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  6. Baranov KO. Searching for ligands of the FcR-like B cell-specific receptors. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  7. Taranin A. Molecular Evolution of the FcR- and KIR-like Receptors in Tetrapods. ISDCI 10th International Congress,
    1-6 July 2006, Charleston, USA

  8. Guselnikov S. Evolution of FcR- and KIR-like leukocyte receptors: from Teleostei to Mammalia. Eastern Great Lakes Molecular Evolution Meeting. Koffler Institute for Pharmacy Management, University of Toronto, 30 April 2005, Toronto, Canada