Laboratory of Immunogenetics

Taranin Alexander
Head of the Laboratory

Staff: 
thomson_logo.gif scopus_logo.jpg Taranin Alexander head DSc (Biology) taraninatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Volkova Olga senior research fellow PhD (Biology) volkovaatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Mechetina Lyudmila senior research fellow PhD (Biology) lucieatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Najakshin Alexander senior research fellow PhD (Biology) najakshinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Chikaev Nikolay senior research fellow PhD (Biology) na_chikatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Guselnikov Sergey senior research fellow PhD (Biology) sguselnikovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Gorchakov Andrey senior research fellow PhD (Biology) gorchakovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Kulemzin Sergey senior research fellow PhD (Biology) skulemzinatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg Baranov Konstantin senior research fellow PhD (Biology) baranovatmcb [dot] nsc [dot] ru
thomson_logo.gif scopus_logo.jpg   Chikaev Anton research fellow PhD (Biology) chikaevatmcb [dot] nsc [dot] ru
      Belovezhets Tatiana research assistant   belovezhecatmcb [dot] nsc [dot] ru
      Mayerova Anna engineer   maerovaatmcb [dot] nsc [dot] ru
      Starikovskaya Antonina lab technician   astarikovskaatmcb [dot] nsc [dot] ru
      Chernishova Zoya lab technician   z_chernishovaatmcb [dot] nsc [dot] ru

Former research workers:

Chernikova Daria
Kuznetsova Valeria
Matvienko Daria
Reshetnikova Evdokia
Sizentsova Yana
Sokratyan Arpine

Research: 
EuroMabNet.png

The staff of the Laboratory are participants of EuroMAbNet - the European network of laboratories working in the field of monoclonal antibodies

Recent publications: 
  1. Gorchakov AA, Kulemzin SV, Kochneva GV, Taranin AV. Challenges and prospects of chimeric antigen receptor T-cell therapy for metastatic prostate cancer. Eur Urol, 2019, doi: 10.1016/j.eururo.2019.08.014

  2. Guselnikov SV, Belovezhets TN, Kulemzin SV, Gorchakov AA, Taranin AV. A simple way to increase recovery of the expressed VH and VL genes in single-sorted human B cells.  (doi: 10.2144/btn-2019-0079BioTechniques 67(4): 184-187, 2019

  3. Rudometov AP, Chikaev AN, Rudometova NB, Antonets DV, Lomzov AA, Kaplina ON, Ilyichev AA, Karpenko LI. Artificial anti-HIV-1 immunogen comprising epitopes of broadly neutralizing antibodies 2F5, 10E8, and a peptide mimic of VRC01 discontinuous epitope. (doi: 10.3390/vaccines7030083Vaccines 7(3): 83, 2019

  4. Shcherbakova NS, Chikaev AN, Rudometov AP, Shcherbakov DN, Il’ichev AA, Karpenko LI. Characteristics of artificial immunogens containing peptide mimotopes of HIV-1 epitopes recognized by monoclonal antibodies 2F5 and 2G12. (doi: 10.1007/s10517-019-04504-1) Bull Exp Biol Med 167(2): 259-262, 2019 

  5. Guselnikov SV, Taranin AV. Unraveling the LRC evolution in mammals: IGSF1 and A1BG provide the keys. (doi: 10.1093/gbe/evz102Genome Biol Evol 11(6): 1586-1601, 2019

  6. Kulemzin SV, Matvienko DA, Sabirov AH, Sokratyan AM, Chernikova DS, Belovezhets TN, Chikaev AN, Taranin AV, Gorchakov AA. Design and analysis of stably integratedreporters for inducible transgeneexpression in human T cells and CAR NK-cell lines. (doi: 10.1186/s12920-019-0489-4BMC Med Genom 12 (Suppl 2): 44, 2019

  7. Copur Ö, Gorchakov A, Finkl K, Kuroda MI, Müller J. Sex-specific phenotypes of histone H4 point mutants establish dosage compensation as the critical function of H4K16 acetylation in Drosophila. (doi: 10.1073/pnas.1817274115Proc Natl Acad Sci USA 115(52): 13336-13341, 2018

  8. Matvienko DA, Kulemzin  SV, Smagina AS, Belovezhets TN, Chikaev AN, Volkova OY, Chikaev NA, Koval OA, Kuligina EV, Taranin AV, Gorchakov AA. Analysis of in vitro activity of PSCA-specific CARs in the context of human NK cell line YT. (doi: 10.18620/ctt-1866-8836-2018-7-2-70-77Cell Therapy Transplantation (CTT) 7(2): 70-77, 2018

  9. Reshetnikova E, Guselnikov S, Volkova O, Baranov K, Taranin A, Mechetina L. B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans. (doi: 10.1002/cyto.b.21611Cytometry B Clin Cytom 94(4): 549-704, 2018

  10. Gorchakov AA, Sizentsova YaG, Belovezhets TN, Kulemzin SV, Chikaev AN, Guselnikov SV, Taranin AV. Design and functional analysis of Fn3-based bi-specific cars. (doi: 10.1016/j.ymthe.2018.05.001Mol Therapy 26 (5 S1): 60, 2018

  11. Gorchakov A, Chikaev AN, Kulemzin SV, Volkova OY, Chernikova DS, Matvienko DA, Belovezhets TN, Sokratyan AM, Kuznetsova VV, Taranin AV. ECAR-NK cell platform: enhancing the CAR-mediated NK cell cytotoxicity via blockade of the CD47/SIRPa axis. (doi: 10.1016/j.ymthe.2018.05.001Mol Therapy 26 (5 S1): 199, 2018

  12. Guselnikov SV, Baranov KO, Najakshin AM, Mechetina LV, Chikaev NA, Makunin AI, Kulemzin SV, Andreyushkova DA, Stöck M, Wuertz S, Gessner J, Warren WC, Schartl M,  Trifonov VA, Taranin AV. Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes. (doi: 10.3389/fimmu.2018.01079Front Immunol 9: 1079, 2018

  13. Sato E, Zaboronok A, Yamamoto T, Nakai K, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Isobe T, Mathis BJ, Matsumura A. Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. (doi: 10.1093/jrr/rrx071J Radiat Res 59(2): 101-107, 2018

  14. Kulemzin SV, Gorchakov AA, Chikaev AN, Kuznetsova VV, Volkova OY, Matvienko DA, Petukhov AV, Zaritskey AY, Taranin AV. VEGFR2-specific FnCAR effectively redirects the cytotoxic activity of T cells and YT NK cells. (doi: 10.18632/oncotarget.24078) Oncotarget 9(10): 9021-9029, 2018

  15. Koval O, Volkova O, Kulemzin S, Gorchakov A, Tkachenko A, Nushtaeva A, Kuligina E, Richter V, Taranin A. NK-cell based delivery of anticancer therapeutics. (doi: 10.1093/annonc/mdx711.050) Annals Oncology 28(Suppl 11): 69P, 2017

  16. Gorchakov A, Kulemzin S, Kuznetsova V, Volkova O, Taranin A. FnCARs: a platform expanding the repertoire of proteins targetable with chimeric antigen receptors. Mol Therapy 25(5S1): 272, 2017

  17. Zaboronok AA, Byvaltsev VA, Kanygin VV, Iarullina AI, Kichigin AI, Taranin AV, Volkova OYu, Mechetina LV, Taskaev SYu, Muhamadiyarov RA, Zavyalov EL, Nakai K, Sato E, Yamamoto T, Mathis BJ, Matsumura A. Boron-neutron capture therapy in Russia: preclinical evaluation of efficacy and perspectives of its application in neuro-oncology. New Armenian Med J 11(1): 6-15, 2017

  18. Sherin PS, López-Duarte I, Dent MR, Kubánková M, Vyšniauskas A, Bull JA, Reshetnikova ES, Klymchenko AS, Tsentalovich YP, Kuimova MK. Visualising the membrane viscosity of porcine eye lens cells using molecular rotors. (doi: 10.1039/C6SC05369FChem Sci 8: 3523-3528, 2017

  19. Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov AA. CAR T-cell therapy: Balance of efficacy and safety. Mol Biology 51(2): 237-250, 2017

  20. Kulemzin SV, Chikaev NA, Volkova OY, Kuznetsova VV, Taranin AV, Gorchakov AA. Modular lentiviral vector system for chimeric antigen receptor design optimization. Rus J Bioorg Chem 43(2): 107-114, 2017

  21. Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov АA. Engineering chimeric antigen receptors. Acta Naturae 9(1): 6-14, 2017

  22. Sokratian A, Baranov K, Guselnikov S, Chikaev N, Volkova O, Mechetina L, Taranin A, Gorchakov A , Kulemzin S. Identification of the human SLAMF9-receptor complex. Tissue Antigens 85: 381-382, 2015

  23. Guselnikov SV, Grayfer L, De Jesús Andino F, Rogozin IB, Robert J, Taranin AV. Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis. (doi: 10.1016/j.dci.2015.07.002Dev Comp Immunol 53: 158-168, 2015

  24. Romanets-Korbut O, Najakshin AM, Yurchenko M, Malysheva TA, Kovalevska L, Shlapatska LM, Zozulya YA, Taranin AV, Horvat B, Sidorenko SP. Expression of CD150 in tumors of the central nervous system: identification of a novel isoform. (doi: 10.1371/journal.pone.0118302PLoS One 10(2): e0118302, 2015

  25. Reguzova AY, Karpenko LI, Mechetina LV, Belyakov IM. Peptide–MHC multimer-based monitoring of CD8 T-cells in HIV-1 infection and AIDS 5 vaccine development. (doi: 10.1586/14760584.2015.962520Expert Rev Vaccines 14: 69-84, 2015

Selected talks: 
  1. Gorchakov A. Adnectin-based CARs: pros and cons. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  2. Chikaev A. CD47/SIRPa blockers and CARs: together we stand. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  3. Belovezhets T. Quest for the optimal NK-cell line as a CAR carrier. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  4. Kulemzin S. Forging the Natural Killer with genome editing. XII Raisa Gorbacheva Memorial International Symposium "Hematopoietic Stem Cell Transplantation. Gene and Cellular Therapy", 20-22 September 2018, St. Petersburg, Russia

  5. Kulemzin SV. Generation of NK-cell lines with enhanced therapeutic potential. International congress “CRISPR-2018”, September 10-14, 2018, Novosibirsk, Russia

  6. Matvienko D. PSMA- and PSCA-specific chimeric antigen receptors (CARs) for prostate cancer therapy. The 25th International Students Congress of bio(Medical) Science (ISCOMS 2018) 4-8 June 2018, Groningen, Netherlands

  7. Gorchakov A. Optimal CAR design and development of an ECAR NK cell platform. XI Raisa Gorbacheva Memorial Meeting “Hematopoetic Stem Cell Transplantation. Gene and Cellular Therapy”, Workshop on Genome Editing in Hematology & HSCT, 14-16 September 2017, St. Petersburg, Russia

  8. Mechetina L. Artificial antibodies based on human 10Fn3 scaffold. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  9. Baranov K. Multimeric 10Fn3-based proteins as inductors of anti-idiotypic antibodies. 8th EuroMAbNet Meeting, 22-23 September 2016, Opatija, Croatia

  10. Mechetina LV. New intacellular B cell marker FCRLA. 5th EuroMabNet meeting, 23-24 September 2013, Menorca, Spain

  11. Mechetina L. FCRL6 receptor: expression and associated proteins. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  12. Baranov KO. Searching for ligands of the FcR-like B cell-specific receptors. 9th International Conference on Human Leukocyte Differentiation Antigens. 11-13 March 2010, Barcelona, Spain

  13. Taranin A. Molecular Evolution of the FcR- and KIR-like Receptors in Tetrapods. ISDCI 10th International Congress,
    1-6 July 2006, Charleston, USA

  14. Guselnikov S. Evolution of FcR- and KIR-like leukocyte receptors: from Teleostei to Mammalia. Eastern Great Lakes Molecular Evolution Meeting. Koffler Institute for Pharmacy Management, University of Toronto, 30 April 2005, Toronto, Canada

Collaboration: 
  • University of Alabama at Birmingham, AL, USA

  • University of Rochester Medical Center, NY, USA

  • Universitat de Barcelona, Spain

  • Faculty of Medicine, University of Tsukuba, Japan